Banca de DEFESA: MARIA GORETTI DO NASCIMENTO SANTOS

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE: MARIA GORETTI DO NASCIMENTO SANTOS
DATA: 06/07/2012
HORA: 08:30
LOCAL: Sala de Reuniões CONSEC, 2º andar do CCS - UFRN
TÍTULO:

KINETICS OF ZINC STATUS AND ZINC DEFICIENCY IN BERARDINELLI-SEIP SYNDROME


PALAVRAS-CHAVES:

Berardinelli-Seip syndrome
,Venous and oral zinc administration, Zinc kinetics, 
Zinc status.


PÁGINAS: 50
GRANDE ÁREA: Ciências da Saúde
ÁREA: Medicina
RESUMO:

Berardinelli-Seip syndrome (BSS) is a very rare disorder characterized by near-complete absence of adipose tissue from birth or early infancy, hypoleptinemia, hypertriglyceridemia, insulin resistance, diabetes mellitus, and other clinical signals. It is caused by mutations in AGPAT2 or Gng3lg. We evaluated 10 BSS patients and 10 healthy subjects. A single dose of 382.43 μmol zinc was administered intravenously before and after 3 months of oral zinc supplementation. Blood samples were collected from the contralateral arm at 0, 30, 60, 90, and 120 min after zinc injection. Plasma and serum were obtained to measure hematological and biochemical parameters. Urine was collected to measure creatinine, protein, and zinc. Basal serum zinc levels were similar in controls and BSS patients. However, serum zinc profiles were significant reduced in BSS patients in comparison with controls. The change in total-body zinc clearance was more significant in BSS patients, indicating that these patients had suboptimum zinc deficiency.


MEMBROS DA BANCA:
Externo ao Programa - 338236 - ADRIANA BEZERRA NUNES
Externo à Instituição - ALCIDES DA SILVA DINIZ - UFPE
Externo à Instituição - FRANCISCO DE ASSIS ROCHA NEVES - UnB
Presidente - 2549958 - LUCIA DANTAS LEITE
Externo ao Programa - 1306690 - TELMA MARIA ARAUJO MOURA LEMOS
Notícia cadastrada em: 25/06/2012 16:35
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