Banca de DEFESA: JEFFERSON ROMÁRYO DUARTE DA LUZ

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : JEFFERSON ROMÁRYO DUARTE DA LUZ
DATA : 17/11/2016
HORA: 09:00
LOCAL: SALA DE AULA PPGCSA
TÍTULO:

LEAVES OF Licania rigida Benth AND Turnera subulata HAS AN ANTICOAGULANT ACTIVITY BY THROMBIN INHIBITION


PALAVRAS-CHAVES:

Coagulation; Thrombin; Phytotherapic.


PÁGINAS: 75
RESUMO:

Over many years, cardiovascular disease and thromboembolic disorders has been the leading cause of death by disease in the world, being responsible for the death of approximately 17.5 million people by the year 2012 (31% of deaths worldwide). The coagulation system is centrally involved in the formation of venous thrombus. Indications currently defined for anticoagulants include the prophylaxis and treatment of venous thromboembolism, cardioembolic prevention in patients with cardiac arrhythmia or mechanical valve prostheses and secondary prevention in patients with acute coronary syndromes or undergoing percutaneous coronary intervention. Unfractionated heparins and low molecular heparins are used as anticoagulant drugs. However, these compounds are accompanied to several side effects such as thrombocytopenia and a high risk of systemic bleeding. The effect of this problem generated demand for new substances in order to assist prolonged anticoagulant therapy. In this context, this study aimed to evaluate the anticoagulant potential, toxic and hemorrhagic effects from Licania rigida Benth and Turnera subulata leaves, species widely found in semiarid northeast. The crude extracts were obtained from ethanol (50%) and subsequent partition with increasingly polar solvents including hexane and ethyl acetate. Evaluation of extracts for coagulation system showed a large thrombin inhibition capacity (~ 80 to 100% of inhibition), a satisfactory anticoagulant activity by methods of aPTT and PT (100% of activity) and low activity AntiXa (~40% of inhibition). Furthermore, it was observed that these extracts also present a low hemorrhagic effect, as well as, the absence of toxicity in vitro and in vivo models. This study reports the first time the anticoagulant potential of Licania rigida Benth and Turnera subulata.


MEMBROS DA BANCA:
Presidente - 346847 - MARIA DAS GRACAS ALMEIDA
Interno - 1490222 - SILVANA MARIA ZUCOLOTTO LANGASSNER
Externo à Instituição - MARIA DAS DORES MELO - UnP
Notícia cadastrada em: 16/11/2016 15:21
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