Banca de QUALIFICAÇÃO: ALDAIR DE SOUSA PAIVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: ALDAIR DE SOUSA PAIVA
DATA: 15/04/2013
HORA: 09:00
LOCAL: SALA DE AULA 1 - PPGCSA
TÍTULO:

Clinical utility of flow cytometry immunophenotyping in the chronic lymphoproliferative diseases

PALAVRAS-CHAVES:

Chronic lymphoproliferative diseases, Immunophenotyping

PÁGINAS: 24
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

The chronic lymphoproliferative diseases (CLD) are disorders of lymphoid sistens characterized by abnormal proliferation of mature lymphocytes that assaut more B cells, to be also occur in T lymphocyts an natural killer cells. In this study, we studied 50 patients (27 male and 23 female) with CLD. They were immunophenotyped using the flow cytometry with the panel of monoclonal antibody constitued by CD3, CD4, CD5, CD8, CD10, CD19, CD22, CD23, CD25, CD38, CD45, CD16/CD56, HLADR and anti light and heavy chain of immunoglobulin. In adittion, we also investigated information refer to patients as age, sex and clinical and laboratorial date such as: lymphadenopaty, hepatomegaly, splenomegaly, leucometry, counters and cytomorphological analysis of cells in peripheral blood, platelet count and hemoglobim determination. The results demonstrated that 43 cases were B-cell disorders and 7 T-cell CLD. The B cell CLD distribution were: 35 cases of B-cell chronic lymphocytic leukemia (B-CLL), 3 B-cell prolymphocytic leukemia (B-PLL), 3 hairy cell leukemia (HCL), and one case of Waldenstrong macroglobulinemie (MW) and mantle cell lymphoma (MCL). The T-cell disorders were: 4 cases of T-cell prolymphocytic leukemia (T-PLL) and one case of adult T cell leukemia (ATL), Sézary sindrome (SS) and T-cell peripheral lymphoma (T-CPL). The correlation between the immunophenotyping and clinical / laboratorial features demonstrated that lymphadenopaty and hepatomegaly were more frequent clinical date and higt level of circulated leukemic cells was the more frequent laboratorial date of this diseases. This dates demonstrated the importance of immunophenotyping seeking to stablins the malignal origin of patients whit peripheral lymphocytosis.

MEMBROS DA BANCA:
Externo ao Programa - 1375489 - ANA CLAUDIA GALVAO FREIRE GOUVEIA
Presidente - 6349161 - GERALDO BARROSO CAVALCANTI JUNIOR
Interno - 350753 - VALERIA SORAYA DE FARIAS SALES