Banca de QUALIFICAÇÃO: RUBIAMARA MAURICIO DE SOUSA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : RUBIAMARA MAURICIO DE SOUSA
DATE: 04/03/2026
TIME: 09:00
LOCAL: REMOTA
TITLE:

GREEN-SYNTHESIZED SILVER NANOPARTICLES FROM MOMORDICA CHARANTIA AND THEIR ANTIOXIDANT AND CYTOTOXIC PROFILES

KEY WORDS:

Silver nanoparticles, Momordica charantia, Green synthesis, Antioxidant activity, Cytotoxicity.

PAGES: 23
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Nanotechnology has emerged as a strategic tool in pharmaceutical sciences due to its potential to enhance drug delivery, improve bioavailability, and expand therapeutic applications. Green synthesis of metallic nanoparticles using plant extracts represents a sustainable, low-toxicity, and cost-effective alternative to conventional chemical methods. In this study, silver nanoparticles (AgNPs) were biosynthesized using the aqueous extract of Momordica charantia, a medicinal plant rich in phenolic compounds and traditionally used for its antioxidant and pharmacological properties. Nanoparticle synthesis was confirmed by UV-Vis spectroscopy, which revealed a surface plasmon resonance peak at 495 nm. Characterization by AFM, SEM, and DLS showed nanostructures ranging from 24 to 34 nm, demonstrating effective reduction of Ag⁺ ions and formation of stable nanoparticles. Antioxidant assays, including copper and iron chelation, DPPH scavenging, TAC, and hydroxyl radical inhibition, demonstrated a concentration-dependent activity, with DPPH scavenging reaching 96.56% and metal chelation exceeding 80% at higher concentrations. Cytotoxicity evaluation using the MTT assay in 3T3 fibroblast cells indicated no toxic effects, with cell viability remaining above 100% at the highest tested concentration. These findings suggest that biosynthesized AgNPs from M. charantia possess strong antioxidant capacity and high biocompatibility, supporting their potential application in pharmaceutical and biomedical formulations.

COMMITTEE MEMBERS:
Externo à Instituição - JEFFERSON ROMÁRYO DUARTE DA LUZ - UNIFAP
Externa ao Programa - 1055045 - MARCELA ABBOTT GALVAO URURAHY - nullPresidente - 346847 - MARIA DAS GRACAS ALMEIDA THORNTON