Banca de DEFESA: MARIO DUARTE BRITO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MARIO DUARTE BRITO
DATE: 03/11/2025
TIME: 08:30
LOCAL: REMOTA
TITLE:

EFFECTS OF MILK PROTEIN SUPPLEMENTATION COMBINED WITH PHYSICAL EXERCISE ON MUSCULOSKELETAL FUNCTION IN OLDER ADULTS WITH SARCOPENIA, OSTEOPOROSIS, OR OSTEOSARCOPENIA: A SYSTEMATIC REVIEW AND META-ANALYSIS

KEY WORDS:

Nutritional Supplementation; Resistance Training; Sarcopenia; Osteoporosis; Osteosarcopenia; Aging.

PAGES: 26
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

Introduction: Osteosarcopenia, defined as the coexistence of sarcopenia and osteopenia/osteoporosis, affects approximately 18.5% of older adults, especially women over 65 years. These conditions lead to reduced muscle strength and bone mineral density, increasing the risk of falls, fractures, and disability. Milk protein supplementation (MPS) combined with resistance training has been proposed to mitigate these effects, although its effectiveness remains uncertain.

Objective: To evaluate, through a systematic review and meta-analysis, the effects of MPS combined with physical exercise on musculoskeletal function in older adults with sarcopenia, osteoporosis, or osteosarcopenia.

Methods: This review followed the PRISMA guidelines and was registered in PROSPERO (CRD42024555933). Randomized controlled trials assessing MPS combined with exercise in older adults were identified through PubMed/MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Library databases. Primary outcomes included muscle mass, muscle strength, physical performance, and bone mineral density (BMD). Meta-analyses were performed using random-effects models (Hedges’ g), and heterogeneity was assessed with the I² statistic.

Results: Eight randomized controlled trials (n = 605) met the inclusion criteria. The combination of MPS and resistance training significantly improved muscle mass and strength, showing small-to-moderate positive effects (SMD = 0.63 and 0.23, respectively). Effects on physical performance and BMD were variable. Some studies also reported reductions in inflammatory markers and increases in anabolic factors, supporting biological plausibility.

Conclusion: The combination of milk protein supplementation and structured resistance training enhances musculoskeletal outcomes in older adults, representing a safe and promising strategy for managing sarcopenia, osteoporosis, and osteosarcopenia.

COMMITTEE MEMBERS:
Externo à Instituição - CAROLINA CUNHA DE OLIVEIRA - UFS
Interno - 2682821 - EDUARDO CALDAS COSTA
Presidente - 350637 - RICARDO OLIVEIRA GUERRA