Banca de DEFESA: GLÁUCIA MARDRINI CASSIANO FERREIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : GLÁUCIA MARDRINI CASSIANO FERREIRA
DATE: 23/08/2024
TIME: 13:00
LOCAL: REMOTO: https://meet.google.com/few-omvm-kof
TITLE:

ASSOCIATION BETWEEN THIGH MUSCLE COMPOSITION AND MORTALITY IN PATIENTS NEWLY DIAGNOSED WITH COLORECTAL CANCER

KEY WORDS:

Cancer; muscle mass; skeletal muscle radiodensity; skeletal muscle index; mortality; body composition

PAGES: 33
BIG AREA: Ciências da Saúde
AREA: Enfermagem
SUMMARY:

Colorectal cancer (CRC) is one of the main causes of morbidity and mortality worldwide. Patients with RCC often have low skeletal muscle mass, which is associated with a worse prognosis. This multicenter cohort study including adults (> 18 years) analyzed the thigh musculature in patients newly diagnosed with RCC, using computed tomography (CT) as an assessment tool. The CT images were analyzed to assess skeletal muscle (SM in cm²), skeletal muscle index (SMI in cm²/m²), and skeletal muscle density (SMD in HU). Muscle abnormalities (low SM, SMI, and SMD) were defined as values below the gender median. Kaplan-Meyer curves and hazard ratios (HR) for low MWS, SMI, and MDS were evaluated for overall mortality, stratified by sex. A total of 257 patients were included in the final analysis. The mean age of the patients was 62.6 ± 12.1 years and 50.2% (n = 129) were female. In men, low thigh SMI was associated with lower survival (log-rank P = 0.02). In addition, low SMI (cm2/m2) was independently associated with higher mortality rates (adjusted HR 2.08, 95% CI 1.03 to 4.18). It is concluded that CT assessment of the thigh muscles can provide valuable information for clinical management, allowing for more effective strategies to improve survival and quality of life in these patients

COMMITTEE MEMBERS:
Presidente - 1879430 - ANA PAULA TRUSSARDI FAYH
Externo à Instituição - JOSE BARRETO CAMPELLO CARVALHEIRA - UNICAMP
Externo à Instituição - NILIAN CARLA SILVA SOUZA