Banca de QUALIFICAÇÃO: MELINA BEZERRA LOUREIRO
Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.DISCENTE: MELINA BEZERRA LOUREIRO
DATA: 13/03/2014
HORA: 08:30
LOCAL: SALA 7B5 - DEP. DE FARMÁCIA
TÍTULO:
STUDY ON THE ASSOCIATION OF OPG GENE POLYMORPHISMS WITH TYPE 1 DIABETES AND BONE MINERAL DENSITY IN BRAZILIAN PATIENTS
PALAVRAS-CHAVES:
Type 1 diabetes, bone metabolism, diabetic osteopathy, OPG polymorphisms
PÁGINAS: 18
GRANDE ÁREA: Ciências da Saúde
ÁREA: Medicina
RESUMO:
The underlying mechanisms triggering changes on BMD in T1DM patients are not well known. Our aim was to investigate the association between children and adolescents with T1DM and the 1181 G>C and 163 A>G polymorphisms of OPG. Furthermore, we also assessed the association of these polymorphisms with alterations on BMD and bone biomarkers. To the best of our knowledge, the present study is the first to evaluate the association of these polymorphisms with T1DM. OPG 1181 G>C and 163 A>G polymorphisms were analyzed in 119 children and adolescents with T1DM and 161 individuals without diabetes (normoglycemic – NG) aged 6 to 20 years old. Glycemic control, laboratorial parameters of bone metabolism and BMD were evaluated. T1DM patients showed a poor glycemic control, and total calcium, CTX and BMD decreased values when compared to NG subjects (p<0.05). OPG 1181 G>C polymorphism might be associated with higher susceptibility to T1DM (p=0,054). Studying only T1DM patients, we evaluated the polymorphisms association with biochemical parameters in various genetic models. OPG-1181 GG carriers showed higher concentrations of ionized calcium in the recessive model (p<0.05). Moreover, the allelic distribution of the OPG 1181 G>C in T1DM with “low bone density for chronological age” showed that 58%of individuals presented the allele G. These results suggest that OPG 1181 G>C polymorphism may contribute to T1DM and diabetic osteophaty development.
MEMBROS DA BANCA:
Presidente - 2323511 - ADRIANA AUGUSTO DE REZENDE
Interno - 349432 - LUCIA DE FATIMA CAMPOS PEDROSA SCHWARZSCHILD
Externo ao Programa - 2087759 - ANDRE DUCATI LUCHESSI