Banca de QUALIFICAÇÃO: JULIANA MENDONCA FREIRE

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: JULIANA MENDONCA FREIRE
DATA: 11/12/2013
HORA: 09:00
LOCAL: SALA DE AULA 01 - PPGCSA
TÍTULO:

Clinical utility of flow cytometry immunophenotyping in acute myeloid leukemia

PALAVRAS-CHAVES:

Acute myeloid leukemia, Flow cytometry, immunophenotyping

PÁGINAS: 24
GRANDE ÁREA: Ciências da Saúde
ÁREA: Medicina
RESUMO:

The authors conducted a study of immunophenotyping by flow cytometry in samples of bone marrow aspirates from 38 patients with acute myeloid leukemia with a panel of monoclonal antibodies specific for acute leukemias, to correlate with clinical, laboratory and epidemiological features of these patients. Of the 38 subjects studied, 23 cases were male and 15 were female. In relation to the age group we found a greater number of cases in adult patients. With respect to clinical data, it was observed that splenomegaly and hepatomegaly were present in most cases. Immunophenotyping demonstrated a characteristic profile of AML with expression of CD13 and CD33 in all cases and CD34 and CD117 in most cases. The CD14 was reactive in monocytic leukemia and was also observed negativity for lymphoid antigens such as CD19, CD10 and CD3, except that CD7 was present in 5 cases. Regarding cytomorphology, there was a direct correlation between cytomorphology and FAB classification, with the prevalence of type myelo-monocytic (AML-M4). These data demonstrate the importance of immunophenotyping in the differential diagnosis of AML as well as in the monitoring of these neoplasms.

MEMBROS DA BANCA:
Externo ao Programa - 1375489 - ANA CLAUDIA GALVAO FREIRE GOUVEIA
Presidente - 6349161 - GERALDO BARROSO CAVALCANTI JUNIOR
Externo à Instituição - TEREZA NEUMA DE SOUZA BRITO - NENHUMA