Banca de DEFESA: ANDREA LUCIANA ARAUJO DA CUNHA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE: ANDREA LUCIANA ARAUJO DA CUNHA
DATA: 30/08/2013
HORA: 14:00
LOCAL: CONSEC - CCS
TÍTULO:

EXPRESSÃO DAS PROTEÍNAS DE RESISTÊNCIA ÀS MÚLTIPLAS DROGAS Pgp e MRP1 NA LEUCEMIA MIELOBLASTICA AGUDA: UM ESTUDO CLÍNICO – LABORATORIAL

PALAVRAS-CHAVES:

Resistência a múltiplas drogas, Glicoproteina P, Proteína Relacionada a Resistência a Múltiplas Drogas do tipo 1, Leucemia Mieloblástica Aguda. L

PÁGINAS: 98
GRANDE ÁREA: Ciências Biológicas
ÁREA: Bioquímica
RESUMO:

Despite the advances in the cure rate for acute myeloid leukemia, a considerable number of patients die from their disease due to the occurrence of multidrug resistance (MDR). Overexpression of the transporter proteins P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP) confer resistance to the treatment these leukemias. OBJECTIVE: To analyze the expression of the Gpp and MRP1 in patients with AML by flow cytometry (FC) and to determine the correlation between expression and demographic and also clinical and laboratorial variables. METHODS: Bone marrow and peripheral blood samples from 346 patients with a diagnosis of AML were assessed for the expression of Pgp and MRP1 by FC. RESULTS: The expression of Pgp and MRP1 was found in 111 (32.1%) and 133 (38.4%) patients, respectively, with greater prevalence in older patients and lower in adolescents, observing also a high incidence in patients with refractory disease, recurrence and secondary in comparison with the cases of de novo AML. Regarding the laboratory findings, we observed a higher correlation statistically significant between the expression of Pgp and MRP1 in AML CD34+ and FAB AML M7, M5A and M2 and lower the M3 subtype, not observed statistically significant correlation between the phenotype MDR and other laboratory data such with hemoglobin, leukocyte count, platelet count, aberrant expression of lymphoid antigens (CD2, CD7 and CD19) and clinical signs related to the disease. CONCLUSIONS: The results showed that the detection of MDR phenotype by flow cytometry can be a molecular marker for prognosis independent patients diagnosed with AML.

MEMBROS DA BANCA:
Presidente - 6349161 - GERALDO BARROSO CAVALCANTI JUNIOR
Interno - 346138 - ALDO DA CUNHA MEDEIROS
Externo ao Programa - 1375489 - ANA CLAUDIA GALVAO FREIRE GOUVEIA
Externo à Instituição - AMALIA CINTHIA MENESES DO REGO - UnP
Externo à Instituição - WOGELSANGER OLIVEIRA PEREIRA - UERN