Banca de QUALIFICAÇÃO: WALICYRANISON PLINIO DA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: WALICYRANISON PLINIO DA SILVA
DATA: 28/02/2013
HORA: 09:00
LOCAL: Sala de aula do PPGCSA prédio do Centro de Ciências da Saúde
TÍTULO:

 Genotyping and virulence factors of Candida albicans isolated from the oral cavity of kidney transplant recipients of two geographic regions of Brazil.


PALAVRAS-CHAVES:

Keywords: Candida albicans, oral candidiasis, kidney transplant recipients, genotyping, virulence factors.


PÁGINAS: 32
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
SUBÁREA: Análise Toxicológica
RESUMO:

Candida albicans is a diploid yeast that in some circumstances may cause oral or oropharyngeal infections. This study aimed to determine the genotypes of 48 clinical isolates of C.albicans obtained from the oral cavity of kidney transplant patients from two distinct geographic regions of Brazil. In addition, we investigated four virulence factors in vitro: protease and phospholipase activities, morphogenesis and the ability to evade from polymorphonuclear neutrophils. The genotype A was the most prevalent (30 isolates; 62.5%), followed by genotype C (15 isolates; 31.5%) and genotype B (3 isolates; 6.25%). When Microsatellite technique with primer M13 was applied, 80% of the isolates from the South were placed within the same cluster. All Genotype C strains were grouped together within two different clusters. Genotype C was considered more proteolytic and resistant to PMNs attack than genotypes A and B, whereas genotype A had higher phospholipase activity. Strains isolated from the South of Brazil showed higher expression of proteinase activity and better ability to combat PMNs phagocytosis. We found a high rate of genotype C strains isolated from the oral cavity of this group of patients. This study characterized oral C.albicans strains isolated from kidney transplant recipients and will contribute for the better understanding of the pathogenesis of oral candidiasis.


MEMBROS DA BANCA:
Presidente - 2323511 - ADRIANA AUGUSTO DE REZENDE
Externo ao Programa - 1452833 - MARIA CELESTE NUNES DE MELO
Externo ao Programa - 1801992 - PAULA RENATA LIMA MACHADO
Notícia cadastrada em: 20/02/2013 11:50
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