Banca de QUALIFICAÇÃO: CINTHIA RAQUEL DA COSTA PORTO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: CINTHIA RAQUEL DA COSTA PORTO
DATA: 20/06/2012
HORA: 10:30
LOCAL: Anfiteatro do Dep. de Biofísica e Farmacologia - CB
TÍTULO:

Anti-inflammatory and antinociceptive activities of Phyllanthusniruri L. spray-dried standardized extract


PALAVRAS-CHAVES:

Phyllanthusniruri, antinociception, anti-inflammation, standardization


PÁGINAS: 20
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Phyllanthusniruri spray-dried standardizedextract (PnSDE) was studied for its anti-inflammatory and antinociceptiveactivities in adult albino rats and mice. The anti-inflammatory effect of PnSDE was observed in carrageenan-induced paw edema and thioglycolate-induced leukocyte migration, while antinociceptive effects were observed using Randall and Selitto, tail flick, and hot plate tests. This study showed thatintraperitonealPnSDE at 100, 200, 800, or 1600 mg/kgreduced the vascular response in the inflammatory process of paw edema induced by 1% carrageenan. Oral PnSDE at 100 or 200 mg/kg inhibited leukocyte migration to the site of inflammation induced by 3% thioglycolate. In rats, at 100 and 200 mg/kg intraperitoneally, the extract exhibited a marked peripheral analgesic effect in a Randall-Selitto assay and showed significant central analgesic activity in a hot plate and tail flick assay. In conclusion, this study suggested that Phyllanthusniruri spray-dried standardized extract (PnSDE),haspotent inflammatory and antinociceptive activities and thatthese activities are not modified by standard drying process, making itfeasible to use the dry extract standardized to obtain a phytotherapicpreparationand thus validating its use for the treatment of pain and inflammation disorders.


MEMBROS DA BANCA:
Presidente - 2374605 - AURIGENA ANTUNES DE ARAUJO
Externo ao Programa - 347338 - EDDA LISBOA LEITE
Interno - 1306690 - TELMA MARIA ARAUJO MOURA LEMOS
Notícia cadastrada em: 15/06/2012 10:06
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