Banca de QUALIFICAÇÃO: VICTOR HUGO REZENDE DUARTE

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : VICTOR HUGO REZENDE DUARTE
DATA : 29/11/2016
HORA: 09:00
LOCAL: SALA DE AULA II DO PPGCF
TÍTULO:

SNPs influence TREML4 mRNA expression levels in the extent of coronary lesion


PALAVRAS-CHAVES:

Cardiovascular diseases: Extent of coronary lesion; SNP; Genotyping; Gene expression; TREML4 and Friesinger Index.


PÁGINAS: 37
RESUMO:

The members of the family triggering receptor expressed on myeloid cells (TREM) are associated with the risk and progression of atherosclerosis. We previously reported a correlation between TREML4 upregulation and the severity of acute coronary syndrome. Here, we assessed the relationship of SNP and TREML4 expression with the extent of coronary lesion. One hundred and fifty-one individuals aged 30 to 74 years and undergoing elective cinecoronariography for the first time were enrolled in the present study. The extent of coronary lesion was assessed by the Friesinger index and patients were classified as without lesion (n = 37), low lesion (n = 42), intermediate lesion (n = 46) and major lesion (n = 26). Serum biochemistry, SNPs (rs2803495 and s2803496) and TREML4 mRNA expression in blood were evaluated. Individuals carrying AG/GG genotype (rs2803495) and CT/CC genotype (rs2803496l) show 2.4 and 7.8 times of being in the group of patients with positive TREML4 expression than individuals carrying references genotypes (p-value <0.05, 95%IC 1.0 – 5.7 and p-value <0.01, 95%IC 2.9 – 20.9), respectively. Interestingly, TREML4 expression increase acoording with atheroscletotic burden, it was at least 1.2-fold higher in patients with major lesion than in patients without lesion, low and intermediate lesion (p <0.05). Conclusion, the SNPs (rs2803495 and s2803496) influence in TREML4 mRNA expression levels and this gene is upregulation in patients with coronary artery lesion suggests that these are associated with the progression of cardiovascular disease.


MEMBROS DA BANCA:
Interno - 2323511 - ADRIANA AUGUSTO DE REZENDE
Presidente - 1715308 - GUILHERME MARANHAO CHAVES
Externo ao Programa - 1055045 - MARCELA ABBOTT GALVÃO URURAHY
Notícia cadastrada em: 17/11/2016 14:46
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