Banca de QUALIFICAÇÃO: EDILAMAR PEREIRA DA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: EDILAMAR PEREIRA DA SILVA
DATA: 05/10/2015
HORA: 14:30
LOCAL: SALA DE AULA II DO PPGCF
TÍTULO:

COMPATIBILITY STUDY BETWEEN ATORVASTATIN AND EXCIPIENTS USING DSC AND FTIR


PALAVRAS-CHAVES:

Atorvastatin compatibility study DSC FTIR Pearson´s correlation


PÁGINAS: 16
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

The aim of this study was to characterize atorvastatin and evaluate interactions between atorvastatin and various excipients by DSC and FTIR, using Pearson correlation as a tool to corroborate
possible interactions that it was not possible to evidence in visual analyses. The DSC curves were
16 obtained using a Shimadzu calorimeter, Model DSC - 60 in the aluminum crucible under heating rate of 20 ° C min -1 at a temperature of 25 400 ° C. The spectra of the samples were obtained on a FTIR - ATR 21 model IRprestige Shimadzu spectrophotometer at a wavelength of 700 - 4000 cm-1 on average of 20 scans. The theoretical spectrum was obtained using an ad hoc algorithm. From the analysis of DSC and  evaluation of Pearson´s correlation, it observed physical interactions with excipients: starch glycolate,  pre-gelatinized starch, croscarmellose, sodium lauryl sulfate, magnesium stearate and mannitol. There is no interaction with lactose. then, the pearson's correlation was so important tool to evaluate possible interactions between IPAs and excipients, using FTIR data to corroborate DSC results.


MEMBROS DA BANCA:
Interno - 1789788 - ADLEY ANTONINI NEVES DE LIMA
Interno - 1492900 - CICERO FLAVIO SOARES ARAGAO
Presidente - 1893445 - EUZEBIO GUIMARAES BARBOSA
Notícia cadastrada em: 24/09/2015 16:06
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