Banca de QUALIFICAÇÃO: KAREN CYBELLE DE HOLANDA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: KAREN CYBELLE DE HOLANDA SILVA
DATA: 28/08/2015
HORA: 09:00
LOCAL: SALA DE AULA II DO PPGCF
TÍTULO:

A scaled up microemulsion formulation for insoluble compounds


PALAVRAS-CHAVES:

Microemulsion, amphotericin B, scale up.


PÁGINAS: 16
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

ABSTRACT: The microemulsions are reported to be an important alternative to improve drug solubility, enhance bioavailability, protect it against environmental conditions, extending thereby, the shelf life. However, during the development of this system, the possible combinations of its constituents can reach an endless number. Thus, the aim of this study was to use design of experiment approach and pseudoternary phase diagram to develop a microemulsion formulation easy to prepare and to scale up to pharmaceutical purposes, using amphotericin B as drug model. The selected system presented an isotropic behavior, stable granulometry (11,6 ± 0,023 nm) during the study (180 days), and high amphotericin B content (185 μg/mL). These results indicate that ME could be considered as an efficient and highly stable drug delivery system by providing an increase the poor bioavailability of AmB.


MEMBROS DA BANCA:
Interno - 1789788 - ADLEY ANTONINI NEVES DE LIMA
Presidente - 1639820 - ARNOBIO ANTONIO DA SILVA JUNIOR
Externo ao Programa - 791.023.104-06 - FRANCISCO IROCHIMA PINHEIRO - UFRN
Notícia cadastrada em: 20/08/2015 13:58
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