Banca de QUALIFICAÇÃO: SARAH RAFAELLY ARAÚJO SANTOS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: SARAH RAFAELLY ARAÚJO SANTOS
DATA: 31/08/2015
HORA: 14:00
LOCAL: SALA DE AULA II DO PPGCF
TÍTULO:

THERMAL AND THE PHOTO-STABILITY EVALUATION OF
AMPHOTERICIN B: ABILITY OF PROTECTION A MICROEMULSION SYSTEM


PALAVRAS-CHAVES:

amphotericin B; microemulsions; stability; HPLC


PÁGINAS: 35
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

ABSTRACT: The aim of this study was to evaluate and to compare the active ingredient
amphotericin B (AmB) stability and the amphotericin B incorporated in a microemulsion
system (AmB-ME). In addition, the ability of the microemulsion to protect this molecule
against a degrading atmosphere. Thus, the AmB was subject to a stressful thermal and UV
light radiation condition for 72 hours. HPLC analyses was carried out every 24 hours to
quantify the AmB degradation. The results showed that the AmB molecule has more
susceptibility to light radiation than to high temperature compared to AmB-ME. Furthermore,
AmB and AmB-ME demonstrated a first order Kinect degradation in thermal condition and
UV light exposition as well. The microemulsion system had an interesting performance on the
AmB stabilization under a stressful condition.


MEMBROS DA BANCA:
Presidente - 1789788 - ADLEY ANTONINI NEVES DE LIMA
Interno - 1893445 - EUZEBIO GUIMARAES BARBOSA
Externo ao Programa - 2140814 - FERNANDO HENRIQUE ANDRADE NOGUEIRA
Notícia cadastrada em: 20/08/2015 11:36
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