Banca de QUALIFICAÇÃO: IZADORA DE SOUZA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: IZADORA DE SOUZA
DATA: 30/04/2015
HORA: 15:00
LOCAL: SALA DE AULA II DO PPGCF
TÍTULO:

Phase transition in LBDDS induced by co-solvent N-methylpyrrolidone for obtain praziquantel anti-schistosome drug loaded nanoemulsions


PALAVRAS-CHAVES:

N-methylpyrrolidone, sodium oleate, soybean oil, liquid crystalline, praziquantel


PÁGINAS: 20
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Liquid crystalline mesophases (LC) have an organized molecular arrangement and combining properties of liquid and solid state as the flow of liquids and the ordered and crystalline structure of solids. High- and low energy techniques were used to produce LC. N-methylpyrrolidone (NMP) and sodium oleate interactions with the system were investigated. LC fabricated by high-energy method were characterized by polarizing light microscopy (PLM), surface tension, rheology and droplet size. PLM showed structures that indicated lamellar and hexagonal phases. Surface tension no important difference between the samples was observed. Rheology showed the transition from shear-thinning behavior to Newtonian behavior and droplet size decreased with increasing of NMP. Novel method to obtain lipid based drug delivery system (LBDDS) were developed through LC dilution and drug-loading was tested in. LC fabricated with low-energy method was diluted with water and NMP 10% aqueous solution which droplet size and drug loading were evaluated. The systems diluted with water showed lower range size (165.22 nm- 381.26 nm) and higher drug-loading (40.96 mg/mL - 43.44 mg/mL) when compared with systems diluted with NMP 10% aqueous solution with size range of 399.37 nm - 760.3 nm and drug-loading range of 37.28 mg/mL – 44.12 mg/mL. An increment in the apparent solubility of Praziquantel was achieved from incorporation in dilution of LC.


MEMBROS DA BANCA:
Externo ao Programa - 1753094 - ALCIDES DE OLIVEIRA WANDERLEY NETO
Externo à Instituição - BOLIVAR PONCIANO GOULART DE LIMA DAMASCENO - UEPB
Presidente - 1178187 - ERYVALDO SOCRATES TABOSA DO EGITO
Notícia cadastrada em: 20/04/2015 11:17
SIGAA | Superintendência de Tecnologia da Informação - | | Copyright © 2006-2022 - UFRN - sigaa20-producao.info.ufrn.br.sigaa20-producao