Banca de QUALIFICAÇÃO: ALAINE MARIA DOS SANTOS SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: ALAINE MARIA DOS SANTOS SILVA
DATA: 24/02/2015
HORA: 14:00
LOCAL: SALA DE AULA II DO PPGCF
TÍTULO:

PHYSICOCHEMICAL ASPECTS OF BENZNIDAZOLE LOADED CATIONIC NANOPARTICLES


PALAVRAS-CHAVES:

Cationic nanoparticles. Benznidazole. Emulsification-solvent evaporation. Drug targeting.


PÁGINAS: 30
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Several polymers have been used for cationic nanoparticles production, in which the copolymers of methacrylate have received considerable attention. The purpose of this work was to produce small cationic nanoparticles potentially able to targeting benznidazole for infected cell by parasite T. cruzi. A systematic optimization was performed by using emulsification-solvent evaporation technique and the parameters were monitored by mean particle size, zeta potential measurements, atomic force microscopy (AFM) and drug loading. The parameters of surfactant/polymer ratio, organic phase and type titration method were successfully optimized, which made possible to obtain small cationic nanoparticles narrowed sized about 200 nm with a suitable drug loading efficiency.


MEMBROS DA BANCA:
Presidente - 1789788 - ADLEY ANTONINI NEVES DE LIMA
Interno - 009.983.424-32 - ANA LUIZA PORPINO FERNANDES - UFRN
Externo ao Programa - 1021095 - RAQUEL DE MELO BARBOSA
Notícia cadastrada em: 20/02/2015 10:36
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