Banca de QUALIFICAÇÃO: FRANCISCO ALEXANDRINO JÚNIOR

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: FRANCISCO ALEXANDRINO JÚNIOR
DATA: 30/09/2014
HORA: 15:00
LOCAL: SALA DE AULA 2 DO PPGCF
TÍTULO:

POLY(VINYL ALCOHOL) HYDROGEL LOADED WITH AMPHOTERICIN B
FOR TREATMENT OF CUTANEOUS LEISHMANIASIS


PALAVRAS-CHAVES:

Amphotericin B; Cutaneus leishmaniasis; Drug Delivery System, Hydrogel; Wound Dressing;


PÁGINAS: 30
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Cutaneus leishmaniasis (CL) is a serious public health problem with estimated 0.7 to 1.3 million new cases occurring worldwide annually. The topic therapy is the ideal outpatient treatment for CL because of its ease administration, lower cost and mainly representing an alternative for reducing the toxicity associated with parenteral administration of conventional amphotericin B (AmB). This work aimed to develop Poly(vinyl alcohol) hydrogels loaded with AmB and to characterize its microstructure as a drug carrier, namely aggregations status of AmB in the system, surface morphology, swelling degree, drug release, leishmanicidal activity as wound dressing properties and microbial permeability. The results suggest that AmB was present in the system as a molecular dispersion and its presence among polymeric chains change the solvent sorption rate of the system from less Fickian to Fickian process. Moreover, crosslinked networks
2 HYDROGEL LOADED WITH AMPHOTERICIN B FOR TREATMENT OF CUTANEOUS
LEISHMANIASIS prevents the burst effect and AmB release was driven to simple diffusion mechanism to follow Higuchi kinetic model resulting in efficient leishmanicidal activity. Furthermore, the hydrogels humper water vapor permeation and prevent microbial permeability. This exciting results suggest hydrogels as promissory systems for the topical treatment of cutaneous leishmaniasis


MEMBROS DA BANCA:
Presidente - 1714294 - MARCIO FERRARI
Interno - 1218940 - ANTONIA CLAUDIA JACOME DA CAMARA
Externo ao Programa - 1754360 - WALDENICE DE ALENCAR MORAIS
Notícia cadastrada em: 26/09/2014 16:31
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