Banca de QUALIFICAÇÃO: RENATO CESAR DE AZEVEDO RIBEIRO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: RENATO CESAR DE AZEVEDO RIBEIRO
DATA: 22/09/2014
HORA: 15:00
LOCAL: SALA DE AULA 2 DO PPGCF
TÍTULO:

DEVELOPMENT AND CHARACTERIZATION OF COSMETICS NANOEMULSIONS CONTAINING
Opuntia fícus-indica (L.) MILL EXTRACT AND EVALUATION OF MOISTURIZING EFFICACY


PALAVRAS-CHAVES:

 

KEYWORDS: Nanoemulsion, Opuntia fícus-indica, non-invasive methods, emulsions,
formulation/stability, skin barrier.



PÁGINAS: 36
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

ABSTRACT
OBJECTIVE: This study aimed to develop an oil in water (O/W) nanoemulsion containing Opuntia
fícus-indica (L.) Mill hydroglycolic extract, as well as evaluate preliminary and accelerated
physical stability and its moisturizing efficacy. METHODS: O/W nanoemulsions containing
Opuntia fícus-indica (L.) Mill extract and 0.5% of Xantham gum were prepared. Physical stability
was evaluated by preliminary and accelerated studies. Preliminary tests consisted of
centrifugation for 30 minutes (3000 rpm), thermal stress and freeze-defrost cycles. On
accelerated stability tests the formulations were stored under different conditions: 4 ± 2 °C; 25
± 2 °C (room temperature), 45 ± 2 °C, and 75 ± 5% RH. The macroscopic analyses (appearance,
homogeneity and organoleptic characteristics), pH value, droplet size, polidispersion index (PDI)
and zeta potential were evaluated at different time (24 h after preparation of formulations and
on 7th, 30th and 60th days). Stratum corneum water content and transepidermal water loss
(TEWL) were determined by noninvasive biometrical measurements using Corneometer
CM®825 and Tewameter®. Skin capacitance and TEWL were determined before, and at 1, 2, 3,
4 and 5 h after a single application of the formulations to fields on forearm and to the control
field without formulation. RESULTS: Formulation containing 0.5% of xantham gum (FX) and
formulation containing 0.5% of xantham gum and 1% of Opuntia fícus indica MILL extract (FXE)
were white, homogeneus, fluid and presented characteristic odor after production. Both
formulations were macroscopically stable during preliminary and acelerated stability tests. FX
and FXE presented a pH compatible to skin pH (4,5-6,0); droplet size varying from 92.2 to 233.6
nm; PDI around 0.200 and zeta potential from -26.71 to -47.01mV. FXE was able to increase the
water content of stratum corneum for 5 hours after application on forearm. CONCLUSION: The
O/W nanoemulsions added to 1% of Opuntia fícus-indica (L.) Mill extract developed presented
5 suitable stability for at least for 60 days. Besides, this formulation was able to increase the water
content of stratum corneum showing their moisturizing efficacy.


MEMBROS DA BANCA:
Interno - 1492900 - CICERO FLAVIO SOARES ARAGAO
Externo ao Programa - 1778262 - ELISSA ARANTES OSTROSKY
Externo ao Programa - 1754360 - WALDENICE DE ALENCAR MORAIS
Notícia cadastrada em: 17/09/2014 16:50
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