Banca de QUALIFICAÇÃO: KIVIA MARIA BATISTA MARINHO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : KIVIA MARIA BATISTA MARINHO
DATE: 05/08/2024
TIME: 09:00
LOCAL: Sessão pública realizada por videoconferência: meet.google.com/spd-zvtu-wav
TITLE:

ASSOCIATION BETWEEN INFLAMMATORY BIOMARKERS AND DIETARY PATTERN IN BOYS WITH DUCHENNE MUSCULAR DYSTROPHY

KEY WORDS:

Empirical dietary inflammatory pattern; Inflammatory Cytokines; Dietary Intake ; Muscular Dystrophy

PAGES: 50
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Duchenne Muscular Dystrophy (DMD) is a severe progressive neuromuscular condition characterized by orthopedic, cardiac, and respiratory impairment, often resulting in premature death of the affected individual. Currently, there's no cure. Inflammation plays a crucial role in the disease progression, with high levels of inflammatory markers such as IL-1β, TNF-α, and IL-6 documented in the literature in DMD patients. Although previous research has suggested that certain nutrients and foods may influence systemic inflammation, the specific correlations between the dietary patterns of these patients and inflammatory markers are still poorly understood. This study investigated the possible association between the empirical dietary pattern index (EDIP) and the inflammatory cytokines IL-1β, TNF-α, and IL-6 in DMD patients. The sample consisted of 32 patients, with a mean age of 12.69 ± 5.09 years. No statistically significant correlation was observed between EDIP and inflammatory cytokine levels, with p-values of 0.571 for TNF-α, 0.634 for IL1β, and 0.986 for IL6 in the tests conducted. The median EDIP was -1.042 ± 2.05, indicating a diet considered anti-inflammatory. The limited sample size due to the condition's rarity, the complexity of the disease pathophysiology, and variations in dietary habits in the sample may explain the lack of correlation between the variables. Despite the absence of a direct association, these results provide valuable insights for a broader understanding of the factors involved in DMD progression.

COMMITTEE MEMBERS:
Interna - 3218336 - BRUNA ZAVARIZE REIS
Externa ao Programa - 2549958 - LUCIA LEITE LAIS - nullExterna ao Programa - 2315640 - MARCIA MARILIA GOMES DANTAS LOPES - nullPresidente - 4659679 - SANCHA HELENA DE LIMA VALE