Banca de DEFESA: JULIA CURIOSO PADOVAM

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : JULIA CURIOSO PADOVAM
DATE: 21/03/2024
TIME: 14:30
LOCAL: Sessão pública realizada por videoconferência
TITLE:

Selenium status and associations with nutritional and metabolic parameters in institutionalized elderly people in the city of Natal/RN.

KEY WORDS:

Selenium. Selenoprotein P. Aging. Nursing homes

PAGES: 70
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Chronic inflammation and changes in body composition are consequences of aging, resulting in greater susceptibility to age-related diseases. Selenium (Se) is involved in metabolic processes related to muscle mass, lipid and glycemic profile and anti-inflammatory action. The functionality of Se occurs through selenoproteins, among which, selenoprotein P (SELENOP), acts in the distribution of this element in tissues, antioxidant and anti-inflammatory action. The study aimed to evaluate the plasma intake of Se, SELENOP and dietary Se in institutionalized elderly people and test associations with anthropometric parameters, metabolic profile and inflammatory markers. This is a cross-sectional study, carried out with 72 elderly people living in public and private Long-Term Institutions for the Elderly in Natal/RN. Anthropometric measurements comprised body mass index (BMI), calf circumference (PP) and waist circumference (WC). Daily food consumption was assessed using the direct food weighing method. Plasma Se concentration was determined by inductively coupled plasma mass spectrometry (ICP-MS) and SELENOP enzyme-linked immunosorbent assay (ELISA). Fasting blood glucose, glycated hemoglobin (HbA1c), total cholesterol (TC), high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c) and triglycerides (TG) were quantified to analyze the metabolic profile. The pro-inflammatory biomarkers analyzed were ultrasensitive C-reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) by chemiluminescence. Comparison between variables was performed using the Chi-square test and Student's t test. Correlations between Se in plasma and SELENOP with anthropometric parameters, metabolic profile and inflammatory markers were performed using Spearman's correlation (ρ). Participants were mostly female (72%) with a mean age (SD) of 82.76 (8.55). The mean concentrations of Se in plasma and SELENOP were 93.08 μg/L (26.71) and 31.09 ng/dL (4.83), respectively, with 63.9% of the population presenting Se levels below the established cutoff point. Dietary Se intake was 72.66 μg/day (11.89). Plasma Se showed a positive correlation with BMI (ρ = 0.408, p = 0.001). Participants with plasma Se <100 μg/L showed a significant association with low weight categorized by BMI (p=0.04). The majority of participants had elevated HbA1c (65.2%). In turn, those who had lower concentrations of SELENOP had an HbA1c value greater than 5.7% (p=0.049). Selenium intake was lower in those with HbA1c greater than 6.5% (78.9%) (p=0.054). In conclusion, plasma Se was associated with low weight and SELENOP with HbA1c, as well as dietary intake, in institutionalized elderly people in the city of Natal/RN.

COMMITTEE MEMBERS:
Interna - 2323511 - ADRIANA AUGUSTO DE REZENDE
Externa à Instituição - Graziela Biude Silva Duarte - USP
Presidente - 6349432 - LUCIA DE FATIMA CAMPOS PEDROSA