Banca de DEFESA: ANA CAROLINA COSTA CAMPOS MOTA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ANA CAROLINA COSTA CAMPOS MOTA
DATE: 25/03/2024
TIME: 09:00
LOCAL: Departamento de Nutrição da UFRN
TITLE:

Overweight and obesity and its relationship with the intestinal morphofunctional barrier and the status of vitamin E

KEY WORDS:

alpha-tocopherol, intestinal permeability, nutritional status; obesity.

PAGES: 80
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Overweight and obesity are a serious public health problem and entail high costs to health systems. Changes in the intestinal morphofunctional barrier (BMI) were observed in animal models of obesity, however, few studies have evaluated this theme in humans. Vitamin E is stored in adipose tissue and appears to be related to overweight and obesity. However, some studies have shown positive associations with overweight, while others have shown negative associations. The relationships between vitamin E and BMI in the context of overweight and obesity have shown inconsistent results. This study aimed to determine the relationship between overweight and obesity with BMI and vitamin E status. An observational, quantitative and cross-sectional study was conducted with data collection from September 2019 to March 2020 and November 2021 to March 2023. Sociodemographic, anthropometric data and blood and urine samples were collected. In total, 75 individuals participated in the study, 32 eutrophic (BMI < 25 kg/m²) and 43 overweight/obese (BMI > 25 kg/m²). The evaluation of intestinal permeability was performed by the lactulose/mannitol test. Serum samples of alphatocopherol were analyzed according to the method of Ortega et al (1998) and adapted by Ribeiro et al (2016). Urine and serum samples were analyzed by High Performance Liquid Chromatography (HPLC). Correlations between BMI, BMI parameters and vitamin E were performed using the correlations of Pearson (r) and Spearman (ρ). The Lactulose/Mannitol ratio (L/M) was similar between the groups studied (p = 0.180) and presented a median of 0.028 (0.013; 0.061) in the eutrophic group and 0.020 (0.010; 0.036) in the overweight/overweight group. Serum concentrations of alpha-tocopherol did not differ between the groups studied (p = 0.654). Vitamin E deficiency was present in 30.20% of overweight/obese individuals and 28.10% of eutrophic individuals. In the overweight/obese group, BMI showed positive correlations with insulin (ρ = 0.475, p = 0.000), HOMA-IR (ρ = 0.425, p = 0.005), HOMA-B (ρ = 0.609, p = 0.000) and CRP-US (ρ = 0.031). The percentage of lactulose showed a positive correlation with HDL (ρ = 0.347, p = 0.028), as well as the L/M ratio (ρ = 0.418, p = 0.008). The mannitol percentage showed a negative correlation with HDL (ρ = - 0.371, p = 0.014) and a positive correlation with fasting glucose (ρ = 0.367, p = 0.020). The results showed that there was no change in BMI function and vitamin E status in participants with overweight and obesity when compared to the eutrophic group. However, the biochemical profile variables correlated with the BMI parameters, indicating low-grade inflammation and metabolic changes resulting from overweight.

COMMITTEE MEMBERS:
Interna - 2578619 - ANA HELONEIDA DE ARAUJO MORAIS
Presidente - 2646462 - BRUNA LEAL LIMA MACIEL
Externa à Instituição - RICHELE JANAINA ARAUJO MACHADO - UNICHRISTUS