Banca de QUALIFICAÇÃO: JULIA CURIOSO PADOVAM

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : JULIA CURIOSO PADOVAM
DATE: 19/02/2024
TIME: 14:30
LOCAL: Sessão pública realizada por videoconferência
TITLE:

Selenium status of institutionalized elderly people: a pilot study

KEY WORDS:

Selenium. Older adults. Nursing home. Selenoprotein P

PAGES: 65
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Chronic inflammation and changes in body composition are consequences of aging, resulting in greater susceptibility to age-related diseases. Selenium (Se) is involved in metabolic processes related to muscle mass, lipid and glycemic profile and antiinflammatory action. The functionality of Se occurs through selenoproteins, among which, selenoprotein P (SELENOP), acts in the distribution of this element in tissues, antioxidant and anti-inflammatory action. The study aimed to evaluate the plasma intake of Se, SELENOP and dietary Se in institutionalized elderly people and test associations with anthropometric parameters, metabolic profile and inflammatory markers. This cross-sectional pilot study was carried out with 72 elderly people living in public and private Long-Term Institutions for the Elderly (ILPI) in Natal/RN. Anthropometric measurements comprised body mass index (BMI), calf circumference (PP) and waist circumference (WC). Daily food consumption was assessed using the direct food weighing method. Plasma Se concentration was determined by inductively coupled plasma mass spectrometry (ICP-MS) and SELENOP enzyme-linked immunosorbent assay (ELISA). Fasting blood glucose, glycated hemoglobin (HbA1c), total cholesterol (TC), high-density lipoprotein (HDL-c), low-density lipoprotein (LDLc) and triglycerides (TG) were quantified to analyze the metabolic profile. The proinflammatory biomarkers analyzed were ultrasensitive C-reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) by chemiluminescence. Comparison between variables was performed using the Chi-square test and Student's t test. Participants were mostly female (72%) with a mean age (SD) of 82.76 (8.55). The mean concentrations of Se in plasma and SELENOP were 93.08 µg/L (26.71) and 31.09 ng/dL (4.83), respectively, with 63.9% of the population presenting Se levels below the established cutoff point. Dietary Se intake was 72.66 µg/day (11.89). Participants with plasma Se <100 µg/L showed significant differences in underweight categorized by BMI. In turn, individuals with plasma Se ≥100 µg/L had higher TC concentrations [183.8 (39.96)] mg/dL. SELENOP did not show significant differences in treatment with the independent variables. In conclusion, BMI and TC were associated with plasma Se levels in a pilot sample of institutionalized elderly people.

COMMITTEE MEMBERS:
Externa à Instituição - CARLA SORAYA COSTA MAIA - UECE
Presidente - 6349432 - LUCIA DE FATIMA CAMPOS PEDROSA
Externa ao Programa - 2549958 - LUCIA LEITE LAIS - null