Banca de DEFESA: MELISSA NUNES MOIA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MELISSA NUNES MOIA
DATE: 28/09/2023
TIME: 14:00
LOCAL: Sessão pública realizada por videoconferência
TITLE:

ASSOCIATIONS OF MAGNESIUM, CALCIUM AND THE CALCIUM/MAGNESIUM RATIO IN PLASMA WITH THE COMPONENTS OF THE METABOLIC SYNDROME AND OTHER CARDIOMETABOLIC RISK FACTORS IN ADULTS AND THE OLDER PEOPLE

KEY WORDS:

cardiometabolic risk, lipid profile, HDL-c, total cholesterol, LDL-c.

PAGES: 95
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Evidence indicates that low concentrations of magnesium concomitant with high concentrations of calcium lead to a higher calcium/magnesium ratio (Ca/Mg), whose results have been associated with cardiometabolic risk factors related to Metabolic Syndrome (MS). This study aimed to evaluate the associations between magnesium, calcium and the Ca/Mg ratio in plasma with MS components and other cardiometabolic risk factors, in adults and elderly people with and without MS. This is a cross-sectional study, carried out with participants in the BRAZUCA-Natal Study. Sociobiodemographic data, lifestyle, anthropometric and biochemical parameters were evaluated. Magnesium and calcium concentrations were measured in plasma using inductively coupled plasma mass spectrometry (ICP-MS). A total of 112 participants evaluated for the diagnosis of MS were included, according to the harmonized criteria for MS, and distributed into groups of individuals with and without MS. Linear regression models were run using the hierarchical method to determine associations between elements and other variables. MS was identified in 50% of the population, especially in female participants. There were no significant differences in plasma magnesium and calcium concentrations and Ca/Mg ratio between the studied groups (all p > 0.05). Mean values of magnesium and calcium concentrations in both groups were considered within reference values. However, a frequency of hypomagnesemia of 13.4% was observed, while excess plasma calcium was 16% in the studied population. No correlation was recorded between plasma magnesium and any of the studied cardiometabolic variables (all p>0.05). Calcium concentrations were negatively correlated with HDL-c (r= -0.335; p = 0.000), TAG (r= -0.294; p = 0.002), total cholesterol (r= -0.554; p = 0.000), LDL- c (r= -0.310; p = 0.001) and not HDL-c (r= -0.385; p = 0.000). On the other hand, the calcium/magnesium ratio was also negatively correlated with HDL-c (r= -0.260; p = 0.007), TAG (r= -0.336; p= 0.000), total cholesterol (r= -0.508; p = 0.000), LDL-c (r= - 0.314; p = 0.001), VLDL-c (r= -0.231; p= 0.018), non-HDL-c (r= -0.413; p= 0.000) and combined lipoprotein index (LCI) (r= -0.215; p= 0.028). Linear regression analyses indicated no associations between magnesium and fasting insulin, HOMAIR and hs-CRP (all p>0.05). However, there were associations between plasma calcium and total cholesterol (β= -0.020; p=0.000; R²=0.238), HDL-c (β=-0.046; p=0.005; R²= 0.267). There were also associations between the calcium/magnesium ratio and total cholesterol (β= -0.025; p=0.000; R²= 0.184) and LDL-c (β=0.017; p=0.020; R²= 0.231). These results was indicate no difference in the concentrations of the elements between the groups, however, important associations of calcium and the Ca/Mg ratio with the risk factors related to MS were evidenced.

COMMITTEE MEMBERS:
Externa à Instituição - Graziela Biude Silva Duarte - USP
Presidente - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA
Interna - 2578592 - KARLA DANIELLY DA SILVA RIBEIRO RODRIGUES