Banca de DEFESA: DANIELA ANTUNES PACHECO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : DANIELA ANTUNES PACHECO
DATE: 19/09/2023
TIME: 08:30
LOCAL: Sessão pública realizada por videoconferência
TITLE:

Exposure to the mixture of essential and toxic elements in institutionalized older adults and associations with glycemic control and lipid profile

KEY WORDS:

Chemical elements. Older adults. Nursing homes. Glycemia. Lipids.

PAGES: 58
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Background: Populations are constantly exposed simultaneously to essential and toxic elements. The excess or deficiency of these substances can affect several metabolic functions such as glycemic control and lipid profile. Elderly people have a progressive deficiency in the ability to detoxify by the elements, and at the same time, are susceptible to dyslipidemia and changes in glycemic control.

Aim: to evaluate the association of the mixture of essential and toxic elements in the plasma of institutionalized elderly people and to test the associations with the variables of glycemic control and lipid profile.

Methods: The present cross-sectional study consisted of 149 elderly people living in public and private nursing homes in the city of Natal/RN. Six essential elements (Co, Cu, Fe, Mn, Se and Zn) and ten toxic elements (Al, As, Ba, Cd, Hg, Li, Ni, Pb, Rb and Sr) defined the composition of the mixture, which were evaluated in the plasma by mass spectrometry with inductively coupled plasma (ICP-MS). Bayesian kernel machine regression (BKMR) was used to estimate potential interactions between elements and test associations with blood glucose, glycated hemoglobin, total cholesterol, high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c), and triglycerides. The model was adjusted using the Monte Carlo Markov Chain (MCMC) method using a Gibbs/MetropolisHastings hybrid MCMC algorithm. The covariates gender, age, type of LTCF, race/color, BMI, smoking, alcoholism, and number of comorbidities were used to adjust the model.

Results: The population of elderly people was mostly (60%) ≥ 80 years old. The highest values of the probability of a posteriori inclusion of the groups (PIP) were observed regarding the effect of Fe on total cholesterol (PIP = 0.4192); and of Ba (PIP = 0.6802), Cu (0.3970) and Fe (0.3490) on triglycerides. The responses to exposure in the univariate analysis were approximately linear, except for Fe. No association was observed after fixation of all metals in a specific percentile (25º, 50º, or 75º). The mixture of the elements was negatively associated with total and LDL cholesterol at concentrations below the 40th and 30th percentiles. No association was detected between the mixture of the elements and the parameters of glycemic control.

Conclusion: the mixture of the elements, in lower concentration, was negatively associated with total cholesterol and LDL. Fe played a crucial role in the outcome of total cholesterol. These results suggest that lower co-exposure to a mixture of essential and toxic elements indicated a lower risk of increasing total cholesterol and LDL-c in the study population.

COMMITTEE MEMBERS:
Externo ao Programa - 2087759 - ANDRE DUCATI LUCHESSI - nullInterna - 3218336 - BRUNA ZAVARIZE REIS
Externo à Instituição - CAMILO DE LELIS MEDEIROS DE MORAIS - UECE
Presidente - 6349432 - LUCIA DE FATIMA CAMPOS PEDROSA