Banca de DEFESA: MARA RUBIA DE OLIVEIRA BEZERRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MARA RUBIA DE OLIVEIRA BEZERRA
DATE: 22/05/2023
TIME: 14:00
LOCAL: Sessão pública realizada por videoconferência
TITLE:

Charlson comorbidity index and its association with body composition and overall survival of newly acquired patients with colorectal cancer: a multicenter longitudinal study

KEY WORDS:

neoplasia, skeletal muscle mass, abdominal fat, myosteatosis

PAGES: 41
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Cancer is one of the main causes of death in most countries, and in Brazil the context is similar. Estimates indicate that there will be approximately 704,000 new cases of cancer per year in Brazil for each three-year period 2023-2025. Of these, colorectal cancer (CRC) stands out with its high incidence. In addition to the diagnosis of cancer, the presence of comorbidities can impact the body composition and prognosis of these patients. Thus, knowing these characteristics is necessary to carry out interventions that will improve the quality and survival of this population. Therefore, the aim of this study was to analyze the association of the Charlson`s comorbidity index adjusted to age (A-CCI) with body composition and overall survival of patients newly diagnosed with CRC. This is a multicenter longitudinal study, which evaluated patients of both sexes, adults and elderly with a recent diagnosis of CRC. Computed tomography (CT) images of the abdominal region were analyzed to determine body composition: skeletal muscle mass area (SMA), skeletal muscle index (SMI), skeletal muscle radiodensity (SMD), visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). Comorbidities were recorded and scored. A total of 436 participants were included in the study, 50% male, the majority (58.3%) non-Caucasian and with a median age of 61 years, approximately half of the patients (50.4%) had no comorbidity, and among those who did, the most prevalent were the presence of solid metastatic tumor (24.1%), followed by uncomplicated diabetes mellitus (16.1%), kidney disease (2.3%) and asthma (2.3%). As for the A-CCI score, the median score was 4 (3;6). Significant and negative correlation between A-CCI and SMD was observed (r = -0.234, p < 0.001). COX regression results after adjusting for confounding variables indicated that patients with a high A-ICC and low SMD had a higher risk of 36-month mortality (OR = 1.53; 95% CI: 1.8 – 2.18), while the phenotypes “low A-CCI and high SMD” and “low A-CCI and low VAT” were associated with lower risk of 36-months mortality. our findings indicate an association between SMD, VAT and comorbidity burden in patients with CRC, and the association these characteristics may increase the mortality risk.   In conclusion, our findings indicate an association of SMD and comorbid burden, and the association between high A-CCI and low SMD increased mortality risk.

COMMITTEE MEMBERS:
Presidente - 1879430 - ANA PAULA TRUSSARDI FAYH
Externa à Instituição - FLÁVIA MORAES SILVA - UFCSPA
Externo à Instituição - JOSE BARRETO CAMPELLO CARVALHEIRA - UNICAMP