Banca de DEFESA: ANNY CRISTINE DE ARAUJO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ANNY CRISTINE DE ARAUJO
DATE: 13/04/2023
TIME: 14:00
LOCAL: Sessão pública realizada por meio de vídeo conferência
TITLE:

Effect of maternal diet on micronucleus frequency in pregnant women and newborns: a systematic review

KEY WORDS:

Mother-child relations. Micronucleus test. Maternal diet. Systematic review

PAGES: 70
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

The effect of diet on maternal and infant genetic levels has been reported in the literature. Diet-associated DNA damage, such as the presence of micronuclei (MN), may be related to an increased risk of developing chronic diseases such as cancer. There is particular concern about this damage during pregnancy as it may affect the newborn (NB). Thus, this review aims to summarize the primary evidence of the impact of diet on the frequency of MN in the mother-infant population. This review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under registration number: CRD42022302401. For elaboration, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol (PRISMA-P) guidelines were considered. PubMed, Embase, Web of Science, Scopus, Science direct databases were used to search for observational studies. Google Scholar and manual search were required to perform the “grey literature” search. Inclusion criteria were observational studies that evaluated the diet consumed by pregnant women (without chronological and gestational age restriction) using a food consumption frequency questionnaire (FFQ) and investigated the frequency of MN in these women and their NBs. No restrictions were applied regarding year of publication and language. Data analysis and extraction was performed by three reviewers independently. The methodological quality of the studies was assessed using the Newcastle-Ottawa Scale (NOS). The co-occurrence of the terms included in the articles was verified and a synthesis was carried out for the main findings of the selected ones. The search strategy retrieved 4558 records. Of these, 13 were read in full and 5 were included in the review. Most studies were of the cohort type (n= 4) and were carried out in the European region. A total of 875 pregnant women and 711 newborns were evaluated. Despite insufficient evidence to confirm that the diet changes the frequency of MN, the included studies found possible effects on the consumption of fried red meat and processed meats and the adequate consumption of vegetables and polyunsaturated fats. Future research is needed so that we can understand the effects of diet on genetic stability and have evidence to help plan public policies on food and nutrition or reinforce protective dietary patterns for this and future generations.

COMMITTEE MEMBERS:
Externa à Instituição - ANA LETÍCIA HILARIO GARCIA - UNILASALLE
Presidente - 2323511 - ADRIANA AUGUSTO DE REZENDE
Interna - 2578592 - KARLA DANIELLY DA SILVA RIBEIRO RODRIGUES