Banca de DEFESA: MARIA EDUARDA BEZERRA DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MARIA EDUARDA BEZERRA DA SILVA
DATE: 28/03/2023
TIME: 09:00
LOCAL: Departamento de Nutrição
TITLE:

CONSUMPTION OF NATURAL OR ADDED FRUCTOSE AND ITS RELATIONSHIP WITH HEPATIC MARKERS IN ADOLESCENTS WITH OVERWEIGHT

KEY WORDS:

Non-alcoholic fatty liver disease; alanine aminotransferase; ultra-processed foods; teenagers; overweight.

PAGES: 62
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Non-alcoholic fatty liver disease (NAFLD) has several stages, from the deposition of lipids in the hepatic parenchyma to cases of hepatitis, fibrosis, cirrhosis and hepatocellular carcinoma. In situations of liver injury, there is an increase in the concentrations of liver transaminases, especially alanine aminotransferase (ALT). Inadequate food intake has been considered one of the causal factors for the development and progression of this disease. In this context, currently, fructose, especially from unnatural sources, has been studied as an independent causal factor in the development of NAFLD and unfavorable metabolic outcomes. Thus, the objective of this study is to investigate the relationship between fructose consumption according to its origin, based on the type of food processing, with liver markers and metabolic parameters in overweight adolescents. This is a cross-sectional study with adolescents aged 10 to 19 years old, diagnosed with overweight or obesity. Anthropometric data (height, weight and waist circumference), biochemical data (lipid profile, glucose profile and concentrations of ALT, AST, GGT and alkaline phosphatase) were collected, and two 24-hour recalls were applied to analyze food consumption. Habitual food consumption was estimated using the Multiple Source Method (MSM). To quantify the fructose consumed, the foods present in the recall were matched with those present in the Food Standards Australia New Zealand. Soon after, the foods were classified according to the food groups of the NOVA classification, according to their type of processing. With this, the amount of fructose from each food group was calculated. The foods were then divided into two groups, according to the origin of the fructose: natural (in natura and minimally processed foods) or added (processed and ultra-processed foods). In data analysis, descriptive statistics procedures of mean and standard deviation and mean confidence interval were used for quantitative variables and frequency distribution and their 95% confidence intervals (95%CI) for categorical variables. To identify possible differences in the profile of adolescents, the chi-square test was applied for categorical variables and the Student's “t” test or Anova for comparison of means. To verify the association between fructose consumption and the nutritional and metabolic profile, linear regression analyzes were performed for continuous variables and logistic regression for categorical variables. All statistical tests were considered at a significance level of 95% (p <0.05). In the population, 91 were boys and 83 were girls, in which we found changes to ALT in 55.1% of boys and 44.9% of girls; for TG, in 51.3% in boys and 48.7% in girls and in HDL-c, 56% in boys and 44% in girls with values below the recommended level. Boys had a higher level of physical activity (p=0.032), higher caloric intake from the diet (p=0.011), higher serum AST (p=0.003) and phosphatase (p<0.001). The foods that most contributed to the average amount of fructose were açaí, in the natural fructose group, and soft drinks in the added fructose group. The consumption of added fructose showed an association with an increase in TG values, in which added fructose was associated with a greater risk of an increase in triglycerides (B= 1,546; 95%CI: 2,144), being up to 54.6%, regardless of of the fit. There was no association in the other variables. Thus, it is evident that the consumption of added fructose from the processed and ultra-processed food groups was related to an increase in TG concentrations in overweight adolescents, however, no association was found with changes in ALT concentrations.

 

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