Banca de QUALIFICAÇÃO: MARA RUBIA DE OLIVEIRA BEZERRA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : MARA RUBIA DE OLIVEIRA BEZERRA
DATE: 03/03/2023
TIME: 08:30
LOCAL: Sessão pública realizada por videoconferência
TITLE:

Charlson comorbidity index and its association with body composition and overall survival of newly acquired patients with colorectal cancer: a multicenter longitudinal study

KEY WORDS:

neoplasia, mortality, skeletal muscle mass, abdominal fat, myosteatosis

PAGES: 41
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Cancer is one of the main causes of death in most countries, and in Brazil the context is similar. Estimates indicate that there will be approximately 704,000 new cases of cancer per year in Brazil for each three-year period 2023-2025. Of these, colorectal cancer (CRC) stands out with its high incidence. In addition to the diagnosis of cancer, the presence of comorbidities can impact the body composition and prognosis of these patients. Thus, knowing these characteristics is necessary to carry out interventions that will improve the quality and survival of this population. Therefore, the aim of this study was to analyze the association of the Charlson comorbidity index (CCI) with body composition and overall survival of patients recently diagnosed with CRC. This is a multicenter longitudinal study, which evaluated patients of both sexes, adults and elderly with a recent diagnosis of CRC. Computed tomography (CT) images of the abdominal region were analyzed to determine body composition: skeletal muscle mass area (SMA), skeletal muscle index (SMI), skeletal muscle radiodensity (SMD), visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). A total of 436 participants were included in the study, 50% male, the majority (58.3%) nonCaucasian and with a median age of 61 years, approximately half of the patients (50.4%) had no comorbidity, and the most prevalent was uncomplicated diabetes mellitus (16.1%). As for the CCI score, the median score was 2 (1;3) for the original score and 4 (3;6) for the age-adjusted version (A-CCI). Binary logistic regression results indicated that only A-CCI was associated with low SMD (OR = 2.90, 95% CI: 1.73-4.76) at diagnosis. Both scores were associated with the risk of mortality at 36 months (OR = 3.51, 95% CI: 2.51–4.93; OR = 3.59, 95% CI: 2.17–5.95 for CCI and ACCI, respectively). In conclusion, CCI and A-CCI are predictors of mortality in patients newly diagnosed with CRC, but only A-CCI was associated with low SMD.

COMMITTEE MEMBERS:
Presidente - 1879430 - ANA PAULA TRUSSARDI FAYH
Externa à Instituição - FLÁVIA MORAES SILVA - UFCSPA
Externa à Instituição - Gabriela Villaça Chaves - INCA