Banca de QUALIFICAÇÃO: ANGELICA LOPES DE SOUSA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ANGELICA LOPES DE SOUSA
DATE: 30/01/2023
TIME: 14:00
LOCAL: Sessão pública realizada por videoconferência
TITLE:

Characterization of the status of essential and toxic elements in institutionalized elderly people

KEY WORDS:

Micronutrients. Toxic metals. Aged. Homes for the Aged. Principal component analysis.

PAGES: 57
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Aging is associated with physiological, anatomical, biochemical and psychological changes that reflect on the health and nutrition conditions of individuals. Maintaining adequate micronutrient status is important for health and longevity. Essential elements participate in important biological processes, and on the other hand, toxic elements are accumulated in the human body. throughout life, resulting in biological damage upon prolonged exposure. Based on these aspects, research on the identification of these multiple elements and how they behave in organic interactions emerge. The retrospective cohort study aims to evaluate the concentrations of essential and toxic elements in institutionalized elderly people and test associations between the grouping of multiple or isolated elements and sex, age group, type of long-stay institution (ILPI), time of institutionalization, number of comorbidities, body mass index, calf circumference and smoking. The population consisted of 149 elderly people living in public and private ILPIs in the city of Natal. Data on demographic, clinical, anthropometric, health and lifestyle variables were obtained and categorized according to specificities. Food consumption was measured using the direct food weighing method. The calculation of micronutrient inadequacy was performed using the Estimated Adequate Requirement (EAR) method as the cut-off point. Six essential and nine toxic elements were evaluated in plasma by inductively coupled plasma mass spectrometry (ICP-MS). Results are presented as median (P25-P75). To understand the variance of the elements in the sampling plan, principal component analysis (PCA) was performed. Plasma concentrations of Cu, Fe and Se were within normal limits. The zinc concentration was below the reference value. The dietary intake of Mg and K had a prevalence of inadequacy above >50%. Four factors identified by the PCA were constituted as follows: C1 (As, Ni, Rb, Cu, Se and Zn); C2 (Cd and Pb); C3 (Al and Mn) and C4 (Li). The first component generated (C1) explained 32.6% of the total variance of the model, with the sum of all loads equal to 67.4%. Associations between factors and independent variables were tested. Pb and Cd were associated with the presence of multicomorbidities (p=0.018), Al de Mn with gender (p=0.012) and type of ILPI (p=0.002). Hg was related to the type of ILPI (p<0.001), BMI (p<0.001), calf circumference (p=0.03) and number of comorbidities p=0.022). Essential and toxic element status was associated with multicomorbidities, type of ILPI, IMC, and calf girth.

COMMITTEE MEMBERS:
Externa à Instituição - CARLA SORAYA COSTA MAIA - UECE
Presidente - ***.476.444-** - LUCIA DE FATIMA CAMPOS PEDROSA - UFRN
Externa à Instituição - MARIA DAS GRACAS ALMEIDA THORNTON - UFRN