Banca de QUALIFICAÇÃO: ANNY CRISTINE DE ARAUJO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ANNY CRISTINE DE ARAUJO
DATE: 20/12/2022
TIME: 09:00
LOCAL: Sessão pública realizada por videoconferência
TITLE:

Effect of maternal diet on micronucleus frequency in pregnant women and newborns: a systematic review

KEY WORDS:

Mother-baby relationship. Frequency of micronuclei. maternal diet. Systematic review

PAGES: 65
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

The effect of diet on maternal and infant genetic level has been reported in the literature. Diet-associated DNA damage, such as the presence of micronuclei, may be linked to an increased risk of developing chronic diseases such as cancer. There is particular concern about these damages during pregnancy as they can affect the newborn. Thus, this review aims to summarize the primary evidence of the impact of diet during pregnancy on the frequency of micronuclei in the maternal-newborn population. This review was registered in the International Registry of Prospective Systematic Reviews on February 17, 2022 (registration: CRD42022302401). For elaboration, we followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol (PRISMA-P) guidelines. We used PubMed, Embase, Web of Science, Scopus, Science direct databases to search for observational studies. Academic Google and manual search were necessary to carry out the research in “gray literature”. In data extraction, researchers independently reviewed the full text and collected information that characterizes the study and its findings. Each step was performed by three reviewers. We verified the co-occurrence of the terms included in the articles and made a qualitative synthesis for the main findings of the selected ones. The search strategy retrieved 276 articles and the gray literature search retrieved 3913 records. Of these, 13 were read in full and 5 were included in the review. Most of the studies were cohort type (n= 4) and were carried out in the European region. A total of 875 pregnant women and 711 newborns were evaluated. Despite little evidence, the included studies found an increased effect on MN frequency with the consumption of fried red meat and processed meats. To date, a possible reduction in MN-type genetic alterations has been found in diets with adequate consumption of vegetables and polyunsaturated fats. Assertively designed studies that better assess dietary information and incorporate other complementary genetic tests are essential for a better understanding of the identified effects. Future research is necessary so that we can have evidence that helps in the planning of public policies on food and nutrition or reinforces protective dietary patterns for this and the next generations.

COMMITTEE MEMBERS:
Presidente - 2323511 - ADRIANA AUGUSTO DE REZENDE
Interna - ***.476.444-** - LUCIA DE FATIMA CAMPOS PEDROSA - UFRN
Externa ao Programa - 1674709 - VIVIANE SOUZA DO AMARAL - null