Banca de QUALIFICAÇÃO: LEDA KARLA MONTEIRO DIAS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : LEDA KARLA MONTEIRO DIAS
DATE: 25/05/2022
TIME: 09:00
LOCAL: Híbrido – Sala de Reuniões do DNUT e Plataforma Google Meet
TITLE:

POLYPHENOLS EFFECT ON INTESTINAL HEATH OF PRECLINICAL STUDIES WITH DIET-INDUCED OBESITY: SYSTEMATIC REVIEW AND META-ANALYSIS

KEY WORDS:

dysbiosis, phytochemical, inflammation, gut microbiota, obesity

PAGES: 60
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Polyphenols ingestion by diet can set part of strategies in the obesity treatment through its antioxidants, anti-inflammatories, and gut microbiota modulation effects. These actions influence widely the organism including the intestine. In this sense, systematization of scientific data regarding the effects and mechanisms of action from polyphenols on the gut health is important to lead strategies to combat the obesity. The study objective is to gather evidence about the impact of polyphenolic compounds on intestinal health of experimental models with diet-induced obesity. The protocol was designed according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P), approved by the International Prospective Register of Systematic Reviews (PROSPERO – CRD42021262445), and published at Medicine journal (DOI 10.1097/MD.0000000000028162). The systematic review is being outlined according to Preferred Reporting Items for Systematic Review and Metanalysis (PRISMA). The following databases were searched: PubMed, Science Direct, Scopus, Web of Science, and EMBASE. Experimental studies included were with rats and mice with diet-induced obesity and treated with isolated polyphenols at any frequency, period, and dose. Initially,1415 publications were retrieved. After title and abstract reading, following the inclusion and exclusion criteria, 183 studies were selected. After reading the entire article, 18 papers were selected. The methodological quality of each selected article was assessed by two independent raters using the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) tool. There was a high agreement degree among the raters (Kappa coefficient > 0.85). The SYRCLE assessment showed grades ranking 4.5 to 7.0 (the maximum grade is 10). The ongoing work is in the phase of extraction and analysis of data, and, subsequently, the systematic review article will be elaborated. The meta-analysis will be done using the static package RevMan Analysis in Review Manager v.5.3. if at least two articles showed clinical and/or methodological and/or statistical homogeneity. Therefore, the final work will enlighten the evidence grade about effects and action mechanisms resulting from treatment with polyphenols on compromised gut health associated with ponderal excess. Moreover, it will contribute to future research about polyphenols used in obesity treatment.

BANKING MEMBERS:
Externa ao Programa - 2495705 - GRASIELA PIUVEZAM
Presidente - 1971809 - JULIANA KELLY DA SILVA MAIA
Interna - 2275877 - THAIS SOUZA PASSOS