Banca de DEFESA: PRISCILA KELLY DA SILVA BEZERRA DO NASCIMENTO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : PRISCILA KELLY DA SILVA BEZERRA DO NASCIMENTO
DATE: 27/09/2021
TIME: 08:30
LOCAL: Sessão pública realizada por meio de vídeo conferência
TITLE:

ZINC STATUS AND THE AUTISTIC SPECTRUM DISORDER IN CHILDREN AND ADOLESCENTS: A SYSTEMATIC REVIEW

KEY WORDS:

autism spectrum disorder, zinc, children, adolescents.

PAGES: 76
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder and its prevalence in children and adolescents has increased over the years. Studies indicate the deficiency of trace elements as one of the factors involved in the etiology of the disorder, with zinc being one of the main trace elements investigated in individuals with ASD. Thus, the aim of this study was to conduct a systematic review of the relationship between zinc status and Autism in children and adolescents. The protocol for this review is registered in the International Prospective Register of Systematic Reviews (PROSPERO), with registration number: CRD42020157907. The methodological guidelines adopted are in accordance with the Preferred Reporting Items for Systematic Reviews and Meta Analyzes (PRISMA) statement. The selection of studies was carried out from an active search in the databases, Pubmed, Scopus and LILACS, using the search descriptors: zinc, trace elements, Biometals, Autism, children, adolescent. The assessment of the methodological quality of the studies was performed using the Newcastle-Ottawa Scale. Thirty-five studies (34 Case-Controls, one Cohort) performed and 13 countries were included, including the USA (20%), China (17%) and Russia (17%), with the largest number of studies. Sample sizes ranged from 20 to 371, and participant ages from 2 to 18 years. Nine types of biological matrices were evaluated in the studies, with hair (51%) and serum (26%) being the most used in the evaluation of zinc concentrations. Significant differences between the zinc concentrations of the TEA and control groups were observed in 15 studies, of which (34%) observed lower zinc concentrations for the TEA group and (9%) with higher concentrations for the TEA group. Children and adolescents with ASD had lower zinc concentrations compared to controls. Intervention studies with zinc supplementation strategies for children and adolescents with ASD should be conducted.

BANKING MEMBERS:
Presidente - 2323511 - ADRIANA AUGUSTO DE REZENDE
Interna - 175.476.444-49 - LUCIA DE FATIMA CAMPOS PEDROSA - UFRN
Externo à Instituição - RICARDO NEY OLIVEIRA COBUCCI - UnP