Banca de DEFESA: RANNAPAULA LAWRYNHUK URBANO FERREIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : RANNAPAULA LAWRYNHUK URBANO FERREIRA
DATE: 21/09/2021
TIME: 15:30
LOCAL: Sessão pública realizada por meio de vídeo conferência
TITLE:

EFFECTS OF SELENIUM SUPPLEMENTATION ON GLYCEMIC CONTROL MARKERS IN HEALTHY RODENTS: A SYSTEMATIC REVIEW

KEY WORDS:

Selenium supplementation, glucose tolerance, glicemic control, insulin, selenoprotein, animal models.

PAGES: 70
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

In vivo and in vitro studies have shown that selenium supplementation has insulin-mimetic action related to the antioxidant activity of this micronutrient. Otherwise, other studies suggest the ingestion of high doses of selenium interferes with insulin signaling, leading to insulin resistance and hyperglycemia. In view of these controversies, this systematic review aimed to answer the following question: “Does Se supplementation affect glycemic control markers in healthy rodents?” The review registered at PROSPERO (CRD42021212011) will be developed based on Preferred Reporting Items for Systematic Review and Metanalysis (PRISMA). Experimental, randomized or non-randomized trials of healthy animal models (rodents) of both sexes, only supplemented with selenium (inorganic, organic or synthetic compounds), regardless of dose, frequency or route of administration, will be included. Fasting blood glucose (FBG) will be considered as the primary outcome and insulin concentration, insulin resistance (HOMA-IR), selenium concentration and GPx expression as secondary outcomes. The process of search, selection, extraction and quality analysis will be carried out independently, by two reviewers. Divergences will be resolved by a third reviewer. Searches will be conducted in the databases Embase, Scopus, Medline-Pubmed, Web of Science and CINAHL. The analysis of risk of bias and methodological quality of the included studies will be performed by SYRCLE and CAMARADES tools, respectively. The search strategy resulted in 1389 articles reported, with 13 studies remaining at the end of the selection. Among the selected articles, 38% (5 articles) had adverse effects on fasting blood glucose, insulin or glycated hemoglobin, after treatment with doses between 5 µmol/kg/day and 4000 µg/kg/day sodium selenite, for 28-30 days. On the contrary, two studies with selenium nanoparticles (SeNPs) suggested protective effects after administration with 100µg/kg/day for 28 days and 0.5ml/day for 7 days. Another 5 studies reported no significant changes in fasting glucose after treatment with sodium selenite. All studies presented a high risk of selection bias (allocation methods, randomization of animals and blinding of evaluators), however, 100% of the articles were free of biased reports of results, with no potential sources of bias found. Methodological quality resulted in scores between 1.5 and 7.0, with 23.1% of studies classified as high quality. Due to heterogeneity in the presentation of results, there was no statistical design and no meta-analysis. However, this systematic review suggests a theoretical model that considers administration dose, treatment time, presence of pre-existing glycemic changes in the experimental model and form of supplemented Se, as variables that influence the effects of Se supplementation on glycemic markers, as well as systematizes the mechanisms involved in the negative regulation of Se in glucose homeostasis in healthy models. These findings point out critically about the risk of excessive administration of supplements and guides If preclinical future studies on this topic.

BANKING MEMBERS:
Externo à Instituição - ERASMO BENICIO SANTOS DE MORAES TRINDADE
Interna - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA
Presidente - 175.476.444-49 - LUCIA DE FATIMA CAMPOS PEDROSA - UFRN
Externo ao Programa - 737.283.220-91 - RICARDO NEY OLIVEIRA COBUCCI - EBSERH