Banca de DEFESA: NÚBIA RAFAELLA SOARES MOREIRA TORRES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : NÚBIA RAFAELLA SOARES MOREIRA TORRES
DATE: 17/09/2021
TIME: 10:00
LOCAL: Sessão pública realizada por meio de vídeo conferência
TITLE:

ASSOCIATIONS BETWEEN NUTRIENT INTAKE, CLINICAL, ANTHROPOMETRIC AND SOCIOBIODEMOGRAPHIC FACTORS AND THE SURVIVAL OF INDIVIDUALS WITH HEART FAILURE

KEY WORDS:

Heart failure; Food consumption; Micronutrients; Mortality.

PAGES: 73
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Inadequate nutrient intake, in addition to unfavorable clinical and anthropometric factors, can lead to worse outcomes in patients with heart failure (HF). This prospective cohort study aims to assess the prevalence of inadequacies of micronutrients, clinical and anthropometric parameters, and associations with survival in 121 adults and elderly patients with HF treated in an outpatient clinic. An average of 3.4 24-hour recalls was used to assess the usual consumption of micronutrients. Participants were divided into moderate and high deficiency groups, and consumption clusters, according to individual assessment of the intake of each micronutrient. Sociobiodemographic, clinical and anthropometric data were collected, and clinical outcomes (hospitalization and mortality) occurred within 24 months. Overall and eventfree survival were calculated by Kaplan-Meier and curves compared by Log-Rank. Cox regression models were built to identify outcome predictor variables. There was a 100% prevalence of inadequate intake of vitamins B1 and D, and more than 80% for vitamins B2, B9, E, and for calcium, magnesium and copper. There were no differences in overall survival and event-free survival between the groups of individuals with moderate and high micronutrient deficiency (HR = 0.94; p = 0.91 and HR = 1.63; p = 0.26, respectively), and between the Cluster with the highest and lowest consumption of calcium, potassium, phosphorus, magnesium and vitamin D (HR = 0.94; p = 0.91 and HR = 1.08; p = 0.84) as well as when the inadequacy of micronutrients was evaluated in isolation (all p>0.05). Excess weight, according BMI, and glomerular filtration rate > 60 mL/min/1.73m2 showed significant associations with better overall survival (both p<0.05). Cox regression models indicated that the New York Heart Association (NYHA) functional class III/IV is an independent predictor of overall, event-free survival, increasing the risk of mortality (HR = 6.70 (2.21 – 20 .29), p = 0.01) and hospitalizations (HR = 5.64, p < 0.01). Adequate weight according to BMI was associated with better overall survival (HR = 4.53, p = 0.02). Thus, individuals with HF treated in an outpatient clinic have a high prevalence of inadequacy of micronutrients. NYHA functional class and BMI are independent predictors of the occurrence of unfavorable clinical outcomes in individuals with HF.

BANKING MEMBERS:
Interna - 1879430 - ANA PAULA TRUSSARDI FAYH
Externa à Instituição - GABRIELA CORREA SOUZA
Presidente - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA
Externa ao Programa - 2315640 - MARCIA MARILIA GOMES DANTAS LOPES