Banca de QUALIFICAÇÃO: FRANCISCA LEIDE DA SILVA NUNES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : FRANCISCA LEIDE DA SILVA NUNES
DATE: 02/07/2021
TIME: 14:00
LOCAL: Sessão pública realizada por meio de vídeo conferência
TITLE:

Essential and non-essential elements and their relationships with cardiometabolic risk factors in adults and the elderly – BRAZUCA Natal Study

KEY WORDS:

Micronutrients, heavy metals, hyperglycemia, dyslipidemia, high blood pressure, overweight, obesity, cardiovascular risk.

PAGES: 55
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Studies have indicated a relationship between levels of essential and non-essential elements and the increase in cardiometabolic risk factors. This study aimed to investigate the levels of zinc, copper, selenium, arsenic, cadmium and mercury and their relationship with cardiometabolic risk factors in adults and elderly. This is a cross-sectional study carried out with 112 individuals of both sexes, adults and elderly, living in the city of Natal/RN, participating in the Brazilian Usual Consumption Assessment Study (BRAZUCA) Natal. Sociodemographic, lifestyle and clinical data were assessed, as well as anthropometric parameters, glycemic and lipid profile, blood pressure, ultra-sensitive C-reactive protein (CRP-hs) and the Global Risk Score (GRS) was calculated. The levels of elements were measured in plasma, whole blood and urine, when appropriate, considering the technique of inductively coupled plasma mass spectrometry (ICP-MS). Linear regression models adjusted for age, sex, smoking and frequency of alcohol consumption were developed to identify the relationship of the elements with cardiometabolic risk factors. Positive correlations were observed between body mass index (BMI) and plasma copper level (β 0.04, R² 3.43, p<0.01) and the copper:zinc ratio (β 3.57, R² 1.64, p=0.02). Waist circumference was positively correlated with plasma copper level (β 0.09, R² 1.58, p=0.03) and copper:zinc ratio (β 9.59, R² 1.76, p=0 .02) and, negatively, with the mercury level in the urine (β – 1.36, R² 7.37, p=0.03). Similarly, fasting blood glucose was positively correlated with plasma copper (β 0.35, R² 7.67, p<0.01) and copper:zinc ratio (β 33.59, R² 6.94, p<0, 01) and negatively correlated with urine selenium (β -0.58, R² 7.49, p=0.02). The latter was also a predictor of the Insulin Resistance Assessment Index – HOMA-IR (Homeostatic Model Assessment – Insulin Resistence) (β -0.06, R² 13.65, p=0.02). Systolic blood pressure was positively correlated with the copper:zinc ratio (β 12.75, R² 11.41, p=0.04) and negatively correlated with urinary selenium level (β -0.41, R² 14, 25, p<0.01) and cadmium (β -35.84, R² 10.94, p<0.01). Diastolic blood pressure was negatively correlated only with cadmium in urine (β -21.40, R² 7.57, p=0.03). Arsenic concentrations in blood (β -27.74, R² 25.71, p=0.02) and urine (β -0.98, R² 23.34, p<0.01) in addition to mercury in the blood (β -0.41, R² 25.69, p=0.02) were predictors of triglyceride levels. In relation to the lipid profile, blood mercury (β -0.06, R² 11.91, p<0.05) and plasma zinc (β 0.17, R² 12.22, p=0.04) were predictors of VLDL cholesterol. Plasma copper (β 0.004, R² 11.35, p<0.01) and the copper:zinc ratio (β 0.72, R² 24.75, p<0.01) were correlated with hs-CRP. Finally, zinc in plasma (β 0.07, R² 64.19, p=0.03) and selenium in urine (β -0.10, R² 62.24, p=0.04) were predictors of GRS. The results show that the levels of essential and toxic chemical elements in different biological matrices are associated with cardiometabolic risk factors and, therefore, can be useful as predictors of cardiovascular risk.

BANKING MEMBERS:
Interna - 2646462 - BRUNA LEAL LIMA MACIEL
Interna - 3218336 - BRUNA ZAVARIZE REIS
Presidente - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA