Banca de DEFESA: TASSIA LOUISE SOUSA AUGUSTO DE MORAIS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : TASSIA LOUISE SOUSA AUGUSTO DE MORAIS
DATE: 24/09/2020
TIME: 08:00
LOCAL: Sessão pública realizada por videoconferência
TITLE:

Effect of nutritional therapy on kidney function, body composition and quality of life in kidney transplant recipients

KEY WORDS:

kidney transplantation; diet therapy; proteinúria; food consumption; protein

PAGES: 161
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Proteinuria, a common clinical condition after kidney transplantation (KTx), has multifactorial causes, but there are indications that high dietary protein intake also influences renal function outcomes. In the late posttransplant there is an indication for nutritional therapy with control of protein intake, however there are gaps on the real impact of interventions on renal function parameters and other posttransplant aspects. The aim of this study was to evaluate the effect of an individualized nutritional intervention in the late posttransplant on renal function, body composition and quality of life of KTx recipients at a University Hospital in Natal / RN. This is a clinical trial, conducted with 20 patients, randomized into a case group (n=10) - with nutritional intervention consisting of an eating plan and individualized nutritional guidelines (1,0 g/Kg of protein) after 60 days of KTx, and control group (n=10) - with nutritional guidelines for posttransplant offered by the hospital. The groups were followed up in the periods of immediate posttransplant (T0), 3 (T3), 6 (T6) and 9 (T9) months after KTx, being evaluated for renal function (urea concentrations, serum creatinine and ACR) , lipid and glycemic profile, dietary assessment (3-day food record), anthropometric measurements (BMI and waist circumference) and body composition (DXA), in addition to the assessment of quality of life (SF-36), level of physical activity (IPAQ) and screening for mental disorders (SRQ20). The results showed a 30% reduction in the mean values of ACR, indicated as the primary outcome, for the case group at T6, and although reduction was also observed for the control group in the same period, there was no significant difference between groups (p = 0.886).There was an improvement in the dyslipidemia, with an adaptation of the mean values of TC, LDL-c and TG, for the case group, still in T6, while in the control this was only observed in T9, however the differences were not significant (p=0,496). The glycemic levels of the case group did not show a reduction, as perceived for the control, in T6, but remained stable and with a tendency to decrease in T9 (p=0,690). Body weight was maintained for patients in the case group, but there was no reduction in the percentage of body fat and an increase in lean mass, as observed for the control group, at T6 (p=0,964/p=0,761). Low protein intake as well as possible fluctuations in body weight in the case group, before 6 months, may have favored the increase in fat mass at T0 (r=- 0,523/p=0,018) and T6 (r=-0,636/p=0,048). As for the quality of life, there was a significant improvement in the score of the 'vitality' domain of the emotional component (p=0,022), for the case group, at T6. In conclusion, the individualized nutritional intervention favored the control of energy and protein intake in the late posttransplant, and this may be important for reducing the risk of proteinuria, improving quality of life and maintaining body weight, however, the composition can be altered with a consequent reduction in muscle mass.

BANKING MEMBERS:
Externa à Instituição - MILENA BARCZA STOCKLER-PINTO - UFF
Presidente - 2323511 - ADRIANA AUGUSTO DE REZENDE
Externo ao Programa - 2917953 - ARTUR QUINTILIANO BEZERRA DA SILVA
Interna - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA