Banca de QUALIFICAÇÃO: TASSIA LOUISE SOUSA AUGUSTO DE MORAIS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : TASSIA LOUISE SOUSA AUGUSTO DE MORAIS
DATE: 20/08/2020
TIME: 08:00
LOCAL: Sessão pública realizada por videoconferência
TITLE:

Effect of nutritional therapy on kidney function, body composition and quality of life in
kidney transplant recipients

KEY WORDS:

kidney transplantation; diet therapy; proteinúria; food consumption; protein.

PAGES: 96
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Nutritional therapy in late kidney posttransplant can promote improvement or reduction of risks associated with kidney function, such as proteinuria, which is a common clinical condition after kidney transplantation (KT), due to several factors, among them, high consumption of protein in the diet. The objective of this study was to  valuate the effect of a personalized nutritional intervention in the late posttransplant period on kidney function, body composition and quality of life of individuals submitted KT in a University Hospital in Natal/RN. This is a clinical trial, controlled and randomized, conducted with 20 patients, distributed in a case group (n=10) - with a nutritional intervention consisting of an eating plan and personalized nutritional guidelines after 60 days of KT (1,0g/Kg of protein), and control group (n=10) - who received the hospital's standardized nutritional guidelines at the time of hospital discharge after KT. The groups were followed up in the periods of immediate posttransplant (T0), T3, T6 and T9 months after KT, evaluated for kidney function (urea concentrations, serum creatinine and albumin/creatinine ratio (ACR)), lipid profile and glycemic, food consumption (3-day food record), anthropometric measurements (BMI and waist circumference) and body composition (double beam X-ray absorptiometry method). In addition, quality of life (SF-36), physical activity level (IPAQ) and screening for mental disorders (SRQ-20) were assessed. As for kidney function, there was a reduction in the ACR values, in both groups, up to T6, being maintained for the case group, in T9, while the control group presented progression of values in the same period. However, only the ACR in T0 was positively correlated with the percentage dietary protein consumption (r=0,499 and p=0,025). As for the lipid profile, there was a reduction and adequacy in the values of total cholesterol, LDL-c and triglycerides for the case group, in all the periods evaluated. On the other hand, in the control group, the adequacy of these parameters was only perceived in T9. Glycemic levels, although borderline at T0, remained adequate in all periods, for both groups. At T6, the mean blood glucose of the patients in the case group was positively correlated with the ACR (p=0,017). Body weight was maintained in the case group until T6, with weight loss being perceived at T9. However, in the control group, there was weight loss up to T6 and a consequent weight gain in T9. There was no reduction in the percentage of body fat in the case group, however, changes in muscle mass did not show an increase in the number of cases of individuals with sarcopenia, when compared with the control group (p=0,747). There was an improvement in the quality of life for patients in the case group, especially in the ‘vitality’ domain of the emotional component (p=0,022), through SF-36, at T6. In conclusion, it was observed that the control of protein intake after KT, represents an indicator of maintenance of kidney function in the long term, reducing trends for negative reflexes such as proteinuria and the body composition of individuals, improving quality of life and corroborating for graft survival.

BANKING MEMBERS:
Presidente - 2323511 - ADRIANA AUGUSTO DE REZENDE
Externo à Instituição - ALEXANDRE COELHO SERQUIZ
Externo à Instituição - MAURICIO GALVAO PEREIRA