Banca de DEFESA: ANA PRISCILLA SILVA DE SOUZA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ANA PRISCILLA SILVA DE SOUZA
DATE: 01/04/2020
TIME: 14:00
LOCAL: Sala de Reuniões do Departamento de Saúde Coletiva DSC/UFRN
TITLE:

EFFECTS OF DIETARY INTERVENTION ON TOXICITY AND QUALITY OF LIFE IN WOMEN WITH BREAST CANCER DURING NEOADJUVANT CHEMOTHERAPY TREATMENT: RANDOMIZED CLINICAL TRIAL

KEY WORDS:

Breast Neoplasms; Diet and Drug Therapy.

PAGES: 106
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Breast cancer is a chronic disease of multifactorial etiology, with an increasing worldwide incidence and with high mortality rates. Among the factors associated with lifestyle, healthy eating is of great relevance not only in prevention, but also during the treatment of this type of cancer. The reduction of toxicities, improved quality of life, better prognosis and increased survival may be reflections of healthy eating practices during cancer therapy. In this sense the present study aimed to evaluate the effects of a nutritional and dietary intervention on the quality of life and toxicities of women with breast cancer who start neoadjuvant chemotherapy. For this a randomized clinical trial was carried out with female patients diagnosed with breast cancer who started neoadjuvant chemotherapy treatment from November 2018 to December 2019, at the Advanced Oncology Center (CECAN), of the North Riograndense League Against Cancer, located in Natal / RN, Brazil. The volunteers were randomized and placed in parallel groups, where the control (CG) and intervention (GI) groups received nutritional advice on healthy eating practices during treatment and, in addition, only the intervention group received an individualized diet plan. The two groups were followed during the first three cycles of chemotherapy, moments in which nutritional, anthropometric, muscle strength, quality of life assessments were performed, using the QLQ C-30 questionnaire from the European Organization for Research and Treatment of Cancer (EORTC), and toxicities, according to the Common Terminology Criteria for Adverse Events (CTCAE) classification. The Chi-square and Fisher's exact tests were used to compare the proportions between groups. With mixed two-way ANOVA, anthropometric and strength data were compared between groups, at the beginning and at the end of the study. The generalized estimation equation was used to verify the effect of group and time interaction on the selected variables. 34 women were followed up, 15 of whom were allocated to the CG and 19 to the IG, with an average age of 45.5 ± 8.6 and 44.3 ± 9.2 years, respectively in each group. Although no significant differences were observed between groups in relation to global health / QOL, within the functional scales, the job function showed a decline in the CG (P <0.001 for interaction). Also, on the EORTC - QLQ-C30 symptom scales, the GI showed less nausea / vomiting (P <0.001 for interaction) and loss of appetite (P <0.001 for time). Regarding toxicities, the GI also had a lower frequency of leukopenia in the third cycle of chemotherapy (P = 0.034) and a lower frequency of abdominal pain in the second cycle of treatment (P = 0.034), when compared to the CG. In conclusion, the results point out that the dietary intervention preserves a domain of quality of life related to the job function, produces reflexes in the occurrence of nausea / vomiting and loss of appetite, being able to reduce the frequency of leukopenia and abdominal pain during the neoadjuvant chemotherapy treatment.

 

BANKING MEMBERS:
Presidente - 1879430 - ANA PAULA TRUSSARDI FAYH
Externa à Instituição - JULIANA FLORINDA DE MENDONCA REGO
Externa à Instituição - SARA MARIA MOREIRA LIMA VERDE