Banca de QUALIFICAÇÃO: FERNANDA LAMBERT DE ANDRADE

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : FERNANDA LAMBERT DE ANDRADE
DATA : 27/05/2019
HORA: 13:00
LOCAL: sala de aula 07 do Departamento de Nutrição
TÍTULO:

ZINC AND COPPER STATUS AND ASSOCIATED FACTORS IN INDIVIDUALS WITH HEART FAILURE

PALAVRAS-CHAVES:

heart failure; zinc; copper; nutritional status; biomarkers.

PÁGINAS: 65
GRANDE ÁREA: Ciências da Saúde
ÁREA: Nutrição
RESUMO:

Heart failure (HF) is a complex clinical condition whose pathophysiological mechanisms result in inflammation and persistent oxidative stress. The imbalance in the homeostasis of zinc and copper micronutrients has been a frequent finding in individuals with HF. The aim was to evaluate zinc and copper status biomarkers and the associations with biodemographic, clinical, nutritional and inflammatory parameters in individuals with HF. This cross-sectional study enrolled 80 adult and elderly individuals with HF, agrouped according to the etiology of HF in ischemic (n=36) and non-ischemic HF (n=44). Biodemographic, clinical, anthropometric, biochemical and dietary data were evaluated. Biomarkers of zinc status (plasma zinc, urine zinc and dietary zinc) and copper (plasma copper, ceruloplasmin and dietary copper) were analyzed. Concentrations of zinc and copper in plasma and urine zinc were determined by the inductively coupled plasma mass spectrometry (ICP-MS) method. Student's t-tests, Mann-Whitney, Chi-square test or Fisher's exact test were used for comparison between groups, where appropriate. The Spearman Correlation test was used to evaluate the associations between the quantitative variables. The results indicated differences between the groups for the variables: age, diagnosis of hypertension and diabetes mellitus, use of antiplatelet and lipid-lowering agents as well as for LDL-c concentrations (all p<0.05). Dietary zinc intake was lower in the ischemic HF group when compared to non-ischemic HF (p=0.019), while dietary copper was higher in subjects with ischemic HF than in non-ischemic HF (p=0.017). Medians of zinc and copper in plasma and ceruloplasmin were within the reference values in subjects with ischemic HF (plasma zinc: 83.5 (76.0 – 91.8) μg/dL; copper in plasma: 109.3 (87.4 –130.4) μg/dL; ceruloplasmin: 24.6 (21.6 - 28.0) mg/dL] and non-ischemic [plasma zinc: 81.2 (72.1 – 92.6) μg/dL; copper in plasma: 104.5 (93.2 – 135.9) μg/dL; ceruloplasmin: 26.1 (22.3 – 31.7) mg/dL], without differences between groups (all p≥0.05). No significant differences were observed in urine zinc between the groups with ischemic and non ischemic HF [371.5 (198.4 – 549.6) μg/24h vs 359.9 (260.5 – 518.2) μg/24h], as well as copper/zinc ratio values [1.25 (1.11 – 1.56) vs 1.36 (1.06 – 1.67)] (both p≥0.05). Copper concentrations in the plasma and copper/zinc ratio were significantly correlated with variables of renal function evaluation, haematological and inflammatory parameters. Negative correlation was found between plasma zinc and age and positive correlation with albumin, whereas urine zinc also correlated positively with glycated
hemoglobin and urea concentrations (all p<0.05). The results suggest that there are no significant changes in zinc and copper status, regardless of the etiology of HF. Hematologic and inflammatory renal function parameters seem to be correlated with the biomarkers of zinc and copper status in individuals with HF.

MEMBROS DA BANCA:
Externo ao Programa - 2087759 - ANDRE DUCATI LUCHESSI
Presidente - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA
Externa ao Programa - 2315640 - MARCIA MARILIA GOMES DANTAS LOPES