Banca de DEFESA: ANGELICA LUIZA DE SALES SOUZA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : ANGELICA LUIZA DE SALES SOUZA
DATA : 16/04/2019
HORA: 15:00
LOCAL: Departamento de Nutrição
TÍTULO:

VITAMIN D STATUS AND CARDIOMETABOLIC RISK FACTORS IN OVERWEIGHT/ OBESITY ADOLESCENTS


PALAVRAS-CHAVES:

Adolescent, Overweight, Obesity, Vitamin D, Vitamin D Deficiency, Risk Factors


PÁGINAS: 60
GRANDE ÁREA: Ciências da Saúde
ÁREA: Nutrição
SUBÁREA: Análise Nutricional de População
RESUMO:

Evidence indicates the high prevalence of  hypovitaminosis D associated with obesity and cardiometabolic disorders in infants and adolescents  worldwide, but few studies have been conducted in sunny urban regions in northeastern Brazil. The aim of the present study was to evaluate the association between vitamin D status and cardiometabolic risk factors in overweight/obese adolescents. This  cross-sectional study carried out by non-probability sampling, involved all adolescents between 10 and 19 years of age, of both sexes, diagnosed as being overweight or obese, who were first seen at the pediatric outpatient clinic of the Onofre Lopes University Hospital / UFRN (Federal University of Rio Grande Do Norte), Natal / RN, from  September 2016 to November 2018. Data relating to clinical, biochemical, anthropometric, physical activity, exposure to sun and skin phototype were evaluated. 25-hydroxyvitamin D (25(OH)D) was analyzed via  chemiluminescence method. The adolescents were agrouped according to 25(OH)D concentrations of "sufficient" (≥30ng/mL) and "hypovitaminosis D" (<30ng/mL). Comparisons of the variables between the groups were carried out using appropriate statistical tests. Correlations between 25(OH)D concentrations and continuous variables were assessed by  Spearman's coefficient (r). The relationship between the independent variables and the 25(OH)D concentration was established and ajusted using the generalized linear regression model (GLM). The sample was composed of 125 adolescents, the majority male, with age range from 10 to 11 years old, with a median age of 11 years old. A frequency  of hypovitaminosis D was of 45.6%. A higher percentage of hypovitaminosis D (56.1%) was found in the females. The mean concentration of 25(OH)D was 32.73 (10.03) ng/mL in general; 39.39 (8.25) ng/mL in the 25(OH)D sufficiency group and 24.38 (4.01) ng/mL in the hypovitaminosis D group, regardless of gender. There were statistically significant associations between hypovitaminosis D and age increase (X²=7.45, p=0.024), arterial pressure (X²=7.56, p=0.006), neck circumference (X²=5.84, p= 0.016), HOMA-IR index (X²=5.84, p=0.016) and arterial pressure_metabolic syndrome (X²=7.56, p=0.006). After adjusting for sexual maturation, serum concentrations of 25(OH)D presented a significant positive correlation with exposure to sun (r=0.321, p=0.000) and physical activity (r=0.189; p=0.034); and a significant negative correlation with arterial pressure (r=-0.288, p=0.001), body weight (r=-0.236, p=0.008), neck circumference (r=-0.200, p=0.025), PTH (r=-0.229, p=0.020), fasting insulin (r=-0.375, p=0.000) and HOMA-IR (r=-0.386, p=0.000). The generalized linear regression model identified a significant negative association between weekly exposure to sun [Odds Ratio (OR)=0.96; confidence interval 95%= 0.92 - 0.99, p <0.05] in the prediction of hypovitaminosis D, and significant positive associations were found between the arterial pressure according to the percentage [Odds Ratio (OR)= 4.00; confidence interval 95%= 1.19 - 13.37, p<0.05], and arterial pressure as the diagnostic criterion for the metabolic syndrome [Odds Ratio (OR)=0.96, 4.73; confidence interval 95%= 1.45 - 15.45, P <0.05], in which adolescents with elevated arterial pressure were four times more likely to present hypovitaminosis D; and significant positive associations between body weight [Odds Ratio (OR)= 1.04; confidence interval 95%= 1.01 - 1.07, p <0.05], and fasting insulin [Odds Ratio (OR)= 1.13; confidence interval 95%= 1,05 - 1.22, p <0.05] as predictors of hypovitaminosis D. It was concluded that low exposure to sun is associated to hypovitaminosis D, and that the reduction of 25(OH)D is positively associated with elevation of arterial pressure, overweight and resistance to insulin in overweight/obese adolescents originating from a sunny region.

 


MEMBROS DA BANCA:
Presidente - 1452705 - SEVERINA CARLA VIEIRA CUNHA LIMA
Interna - 349432 - LUCIA DE FATIMA CAMPOS PEDROSA
Externa à Instituição - NÁGILA RAQUEL TEIXEIRA DAMASCENO - USP
Notícia cadastrada em: 22/03/2019 09:33
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