Banca de QUALIFICAÇÃO: IASMIN MATIAS DE SOUSA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : IASMIN MATIAS DE SOUSA
DATA : 20/02/2019
HORA: 14:00
LOCAL: Sala de Reuniões do Departamento de Saúde Coletiva - DSC/UFRN
TÍTULO:

Skeletal muscle mass in cancer patients: comparison of evaluation methods.

PALAVRAS-CHAVES:

Cancer, muscle mass, computed tomography, calf circumference. 

PÁGINAS: 46
GRANDE ÁREA: Ciências da Saúde
ÁREA: Nutrição
RESUMO:

Cancer is one of the most aggressive and incidental diseases in the world that can impact on body composition including muscle wasting. Severe loss of muscle mass (MM) has been associated with worse outcomes, so it is important to develop studies that investigate methods of MM assessment to identify individuals at nutritional risk. The aim of the study is to compare the prediction of MM by computed tomography images (CT) and calf circumference (CC) and it´s correlation with mortality in cancer patients. A cross-sectional study was conducted with adults and elderly patients attending hospitals of oncology in Natal, Brazil and who had recent abdominal CT images available (< 30 days). Data was collected through form and in the patients' records and included: gender, age, ethnicity, clinical variables (primary site, staging and treatments performed) and outcome (death). Anthropometrical data was accessed for determination of nutritional status (Body Mass Index – BMI) and CC to evaluate low muscle mass. Skeletal Muscle Index (SMI) and Muscle Attenuation (MA) were analyzed by CT images for the evaluation of muscle mass and quality, respectively. Sarcopenia was diagnosed as low muscle strength (handgrip strength) with the presence of low muscle quantity (SMI) or quality (MA). The results included 206 patients, most female (50.5%) and mean age 64.1 ± 13.3 years old. Colorectal cancer was the most prevalent (38.8%) and almost half of the population was classified with normal BMI (49.0%). Low SMI was observed in 28.6% of the patients and 51.5% had low CC, 39.3% had low MA and 34.6% were sarcopenic. We observed a high correlation between CC and skeletal muscle mass for male (r=0.66; p<0.001). Agreement between low SMI and low CC showed better sensibility and negative predictive value for male (70% and 85.4% respectively). In the whole sample, mortality was stronger associated with low CC (p = 0.02), however when stratified for gender, just male presented significative correlation (p = 0.03). In conclusion, low CC was consistent with low SMI obtained by CT images for male patients significant associated with mortality in cancer patients. The findings allow the use of CC as a surrogate to predict low muscle mass when CT analysis is not available.

MEMBROS DA BANCA:
Externa à Instituição - FLÁVIA MORAES SILVA - UFCSPA
Presidente - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA
Interna - 1891751 - URSULA VIANA BAGNI