Banca de DEFESA: LICYANNE INGRID CARVALHO DE LEMOS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : LICYANNE INGRID CARVALHO DE LEMOS
DATA : 30/07/2018
HORA: 09:00
LOCAL: Sala de aula 7 do Departamento de Nutrição - DNUT/UFRN.
TÍTULO:

Antidiabetic, antioxidant and inflammatory response of Allium cepa L. e sulfóxido de S-metil cisteína in rats with streptozotocin-induced diabetes.

PALAVRAS-CHAVES:

Experimental diabetes; Allium cepa L.; S-methyl cysteine sulfoxide; cytokines; antioxidant activity.

PÁGINAS: 60
GRANDE ÁREA: Ciências da Saúde
ÁREA: Nutrição
RESUMO:

Introduction: Extract of Allium cepa L. and its isolated compounds are known to have antidiabetic and antioxidant properties. Here we investigate the antidiabetic, anti-oxidant and anti-inflammatory effects of treatments with Allium cepa L. extract and S-methyl cysteine sulfoxide in rats with streptozotocin-induced diabetes. Methods and results: The groups were divided into: (CG): control group  - non-diabetic animals; STZ: animals with untreated experimental diabetes; STZ-EAC: animals with experimental diabetes treated with Allium cepa L. extract and STZ-SMCS: animals with experimental diabetes treated with S-methylcysteine. Allium cepa L. extract (400mg / kg body weight) and S-methylcysteine (200mg / kg body weight) were administered daily for 30 days. The STZ-EAC and STZ-SMCS groups had lower levels of triglycerides and VLDL, increased SOD and CAT activity, pancreatic islet regeneration and improved glycogen depletion throughout the STZ. Only the STZ-SMCS group showed antidiabetic effect and increased IL-10, compared to STZ and STZ-EAC. Conclusion: Allium cepa L. extract and S-methylcysteine sulfoxide can improve the metabolic profile in DM, attenuating oxidative stress in the liver and the inflammatory response. These results provide a basis for the use of these compounds as nutritional supplements.

MEMBROS DA BANCA:
Externo ao Programa - 1667882 - BENTO JOAO DA GRACA AZEVEDO ABREU
Externo à Instituição - ILLANA LOUISE PEREIRA DE MELO - F.M.Nassau
Presidente - 349432 - LUCIA DE FATIMA CAMPOS PEDROSA