Banca de DEFESA: RAQUEL COSTA SILVA DANTAS KOMATSU

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : RAQUEL COSTA SILVA DANTAS KOMATSU
DATA : 31/07/2018
HORA: 09:00
LOCAL: Auditório da Superintendência de Infraestrutura - SIN/UFRN.
TÍTULO:

Factors associated with vitamin D status in individuals with heart failure living in a sunny region.

PALAVRAS-CHAVES:

Heart failure; vitamin D; vitamin D deficiency.

PÁGINAS: 66
GRANDE ÁREA: Ciências da Saúde
ÁREA: Nutrição
RESUMO:

Hypovitaminosis D has been a frequent finding in individuals with heart failure (HF), however, studies in regions with high solar incidence are scarce. The aim of this study was to evaluate the vitamin D status and its associated factors in individuals with HF residing in a sunny region. This is a cross-sectional study conduced with 70 adult and elderly individuals diagnosed with HF, according to the Boston points system and the Framingham criteria, confirmed by the Doppler echocardiogram. Clinical, biochemical, anthropometric, dietary data, skin phototype, sun exposure and physical activity were evaluated. 25-hydroxyvitamin D (25OHD) was analyzed by electrochemiluminescence immunoassay method. Subjects were agruped according to 25OHD concentrations in"sufficient" (≥30ng / mL) and "hypovitaminosis D" (<30ng / mL). Comparisons of the variables between the groups were performed using appropriate statistical tests. Correlations between 25OHD concentrations and continuous variables were assessed by the Pearson or Spearman coefficient (r). The relationship between the independent variables and the 25OHD concentration was adjusted accordingly using the generalized linear regression model. The individuals had a mean age of 53 (15) years, predominantly male (64.3%). The mean concentration of 25OHD was 40.1 (12.4) ng / mL, with 24.3% of hypovitaminosis D. A significantly higher frequency of females was observed in the hypovitaminosis D group [Odds Ratio (OR ) = 7.38; p = 0.001]. Participants who presented HF with ischemic etiology had a higher risk for hypovitaminosis D (OR = 3.97, p = 0.03), as well as those with high PTHi (> 67pg / mL) (OR = 3.39, p = 0.034 ). Patients with HF using the drug angiotensin receptor antagonist / angiotensinogen converting enzyme inhibitor or antiplatelet agent had a significantly higher chance of hypovitaminosis D (OR = 11.14, p = 0.015 and OR = 5.81, p = 0.003, respectively). Significant correlations were found between 25OHD and albumin (r = 0.365, p = 0.015), total calcium (r = 0.266, p = 0.026), hemoglobin (r = 0.249, p = 0.037), TGP 0.002) and PTHi (r = -0.255, p = 0.033). Analysis of the regression model adjusted for 25OHD showed that sex is an independent predictor of 25OHD concentrations, with 25OHD concentrations being higher in males compared to females (β = 7.78, p = 0.005). The New York Heart Association (NYHA) functional classification also proved to be an independent predictor, and NYHA I subjects were found to have concentrations higher than 25OHD when compared to NYHA class III / IV (β = 8.23; p = 0.032). It is concluded that hypovitaminosis D is a moderately frequent finding among individuals with HF residing in a sunny region. Clinical and biochemical aspects demonstrated associations with 25OHD. Sex and functional classification are independent predictors of 25OHD.

MEMBROS DA BANCA:
Externo à Instituição - FLÁVIA FIORUCI BEZERRA - UERJ
Presidente - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA
Interno - 1804884 - VIVIAN NOGUEIRA SILBIGER