Banca de QUALIFICAÇÃO: ILANNA MARQUES GOMES DA ROCHA
Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.DISCENTE : ILANNA MARQUES GOMES DA ROCHA
DATA : 20/04/2018
HORA: 14:00
LOCAL: Sala de aula 9 do Departamento de Educação Física - DEDFIS/UFRN
TÍTULO:
Toxicitiy in gastrointestinal cancer patients in chemotherapy: association with sarcopenia and cachexia.
PALAVRAS-CHAVES:
Sarcopenia; cachexia; chemotherapy toxicity; nutritional status; gastrointestinal cancer.
PÁGINAS: 72
GRANDE ÁREA: Ciências da Saúde
ÁREA: Nutrição
RESUMO:
Chemotherapy is a systemic treatment of great relevance for cancer patients; however, it can lead to a series of adverse events, called toxicities. In the evaluation of nutritional status, sarcopenia and cachexia have been associated with several unfavorable prognoses in cancer, such as increased toxicity during chemotherapy. Thus, the objective of this study was evaluate the effects of body composition on the occurrence of toxicities and deterioration in the nutritional status and functional capacity of patients during the first three cycles of chemotherapeutic treatment for gastrointestinal cancer. A prospective study was conducted with patients starting the first cycle of chemotherapy. Haematological and gastrointestinal toxicity and the presence of a dose limiting toxicity (DLT) were assessed according to the NCI Common Toxicity Criteria. Functional capacity was evaluated using dynamometry and the performance scale ECOG. Nutritional status was measured by the Subjective Global Assessment Patient-Generated (SGA-PG). Sarcopenia was assessed using skeletal muscle index with computed tomography by measuring cross-sectional areas of the L3 portion (cm2/m2) and classification according to specific cutoff points. Diagnosis of cachexia was performed according to the current consensus, based on involuntary weight loss in the absence of anorexia associated, with presence of sarcopenia. In results, seventy-seven (77) patients were evaluated, with a higher prevalence of males (57.1%) and mean age of 62.2 years. At baseline, the majority of the participants presented adequate nutritional status, with 44.2% at normal range of BMI, and good functional capacity (85%) for ECOG. During chemotherapy, sarcopenic patients had significantly higher degrees of toxicity for anorexia (p = 0.045), nausea (p = 0.044), and leukopenia (0.036). Significant levels of adverse events were found for diarrhea (p = 0.018), nausea (p = 0.002) and anorexia (0.001 and 0.031 in the first and second cycles, respectively). In conclusion sarcopenic and cachectic also presented higher DLT and had worse evolution of nutritional status and functional capacity during the cycles. In conclusion, sarcopenia and cachexia were significantly associated with gastrointestinal and biochemical toxicity, worsening of nutritional status and functional capacity in first 3 cycles of chemotherapy in gastrointestinal cancer patients.
MEMBROS DA BANCA:
Presidente - 1879430 - ANA PAULA TRUSSARDI FAYH
Externo à Instituição - JULIANA FLORINDA DE MENDONCA REGO - LNRCC
Externo ao Programa - 2315640 - MARCIA MARILIA GOMES DANTAS LOPES