Banca de DEFESA: MABELLE ALVES FERREIRA DE LIMA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : MABELLE ALVES FERREIRA DE LIMA
DATA : 04/12/2017
HORA: 08:30
LOCAL: Sala de aula 07 do Departamento de Nutrição - DNUT/UFRN
TÍTULO:

Vitamin D status in kidney transplant recipients: a longitudinal study.

PALAVRAS-CHAVES:

Vitamin D; Chronic kidney disease; Kidney transplantation; Albuminuria.

PÁGINAS: 61
GRANDE ÁREA: Ciências da Saúde
ÁREA: Nutrição
RESUMO:

Hypovitaminosis D has been a frequent finding in renal patients. In kidney transplant recipients, may cause progression of albuminuria, increasing the decline in renal function and the risk of graft loss. The objective of the study is to evaluate the vitamin D status in kidney transplant recipientes and its relation with renal function parameters. This is a longitudinal study developed with 46 kidney transplant recipients at University Hospital Onofre Lopes (HUOL) of the Federal University of Rio Grande do Norte (UFRN) from August 2015 to January 2017. The subjects were evaluated at baseline, 3 and 6 months post-transplantation, being submitted to anthropometric evaluation, application of a sun exposure questionnaire, biochemical evaluation, including 25-hydroxyvitaminD [25(OH)D], and urine collection to evaluate a albumin:creatinine ratio (ACR). Estimated glomerular filtration rate (GFR) was evaluated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The median age of the subjects was 44 years, the majority males gender and brown ethinicity. There was a predominance of individuals with hypovitaminosis D in the three studied times. Of 42 individuals in the 6 months post-transplant, 19 (45.2%) presented hypovitaminosis D at all times and 8 (19.1%) developed hypovitaminosis D at 3 months. It was possible to observe that of the 27 (64.3%) individuals who presented this profile, 10 (37.0%) had no improvement in the GFR. In 6 months, the 25(OH)D correlated negatively with ACR. The ACR of individuals with hypovitaminosis D were higher at 6 months post-transplant (p = 0.037) and the renal parameters tended to be higher in individuals with hypovitaminosis D. At the end of study, 10 (28.3%) individuals presented albuminuria. There was a significant improvement in the renal parameters up to 6 months and the 25(OH)D showed a significant increase from 3 months to 6 months after transplantation. The parathyroid hormone (PTH) had a negative influence on GFR at time zero and correlated positively with ACR at 6 months post-transplantation.It is possible to conclude that there is a high frequency of hypovitaminosis D up to 6 months after renal transplantation, which may be related to poor prognosis of graft function.

MEMBROS DA BANCA:
Presidente - 2323511 - ADRIANA AUGUSTO DE REZENDE
Externo ao Programa - 1451614 - JOSIVAN GOMES DE LIMA
Externo à Instituição - PATRÍCIA BORGES BOTELHO - UnB