Banca de DEFESA: ERIKA PAULA SILVA FREITAS DE OLIVEIRA
Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.DISCENTE : ERIKA PAULA SILVA FREITAS DE OLIVEIRA
DATA : 01/12/2016
HORA: 09:00
LOCAL: Sala de Reuniões do Departamento de Saúde Coletiva - DSC/UFRN.
TÍTULO:
Zinc status and cardiometabolics risk factors in individuals with metabolic syndrome.
PALAVRAS-CHAVES:
Metabolic syndrome, zinc, biomarkers, zinc intake, risk factors, cardiovascular diseases.
PÁGINAS: 72
GRANDE ÁREA: Ciências da Saúde
ÁREA: Nutrição
RESUMO:
Metabolic syndrome (MS) is a multifactorial disease whose pathophysiological alterations that might compromise zinc status. The aim of this study was to evaluate zinc status biomarkers and their associations with cardiometabolic risk factors in individuals with MS. This is a study case-control, developed with 88 adults and elderly with SM, according to the NCEP / ATP-III, and 37 individuals without MS or other clinical condition with influence on zinc status. Clinical and anthropometric assessments were performed and lipid, glycemic, and inflammatory profiles were also obtained. It was evaluated zinc intake, plasma zinc, erythrocyte zinc, and urinary zinc excretion levels. Differences between groups were evaluated by regression models, considering adjustment covariates. Correlations were identified by Pearson coefficient (r). The significance level was 5%. The average age of participants was 50 (11) years and 44 (11) years for the group of patients with MS and controls, respectively, with female predominance in both groups. The average energy intake was significantly higher in patients with MS (p = 0.003) and dietary intake in both groups was characterized as high percentage of protein intake, and a proper percentage of carbohydrate and fat intake. Zinc intake average was significantly lower in MS group compared with control group (p < 0.001). No significant differences were observed in plasma zinc levels (p > 0.05). It was found significantly higher erythrocyte zinc levels in the MS group (p < 0.001) independent from co-variable adjustments. Urinary zinc excretion level was significantly higher in the MS group (p = 0.008), and adjustments for age and sex explained 21% of the difference, (R2 = 0.21, p < 0.001). SM group were found significant associations between zincuria and fasting blood glucose level (r = 0.479), waist circumference (r = 0.253), triglyceride levels (r = 0.360), glycated hemoglobin (HbA1c) levels (r = 0.250), homeostatic model assessment - insulin resistance (HOMA-IR) (r = 0.223) and high-sensitivity C-reactive protein levels (hs-PCR) (r = 0.427) (all p < 0.05). We confirmed the impairments in zinc status in MS group, characterized by increasing the erythrocytes zinc and higher zincuria, despite the inadequacies of zinc intake. Alterations in cardiometabolic risk factors influence zincuria in patients with MS.
MEMBROS DA BANCA:
Externo ao Programa - 2442045 - ANDRE GUSTAVO PIRES DE SOUSA
Externo à Instituição - DILINA DO NASCIMENTO MARREIRO - UFPI
Presidente - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA