Banca de DEFESA: HELOISA FERNANDA LOPES DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : HELOISA FERNANDA LOPES DA SILVA
DATA : 02/12/2016
HORA: 09:00
LOCAL: Sala de aula 07 do Departamento de Nutrição - DNUT/UFRN.
TÍTULO:

Assessment of nutritional status of zinc in patients with Amyotrophic Lateral Sclerosis.

PALAVRAS-CHAVES:

Zinc, Amyotrophic Lateral Sclerosis, Nutritional Status.

PÁGINAS: 71
GRANDE ÁREA: Ciências da Saúde
ÁREA: Nutrição
RESUMO:

Disturbances of zinc homeostasis in nervous system, represented by its excess or deficiency, are associated with numerous neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), contributing to its pathogenesis and progression. Thus, the purpose of this study was to evaluate the zinc status in ALS patients attending a specialized ambulatory care at Onofre Lopes University Hospital, Natal-RN, Brazil. This is a case-control study of 57 individuals, 20 patients with ALS (case group) and 37 healthy subjects (control group). Case group patients were clinically characterized in terms of symptom onset, symptom duration, feeding pathway and score on the ALS functional rating scale. In both groups, body mass index (BMI) was calculated, and dietary energy, protein, fat, carbohydrate, fiber and zinc intake were measured using two 24-hour recalls. Moreover, in both groups, plasma and urinary zinc concentrations were determined by atomic absorption spectrophotometry. Most of the participants were eutrophic, according to BMI, accounting for 73.7% of the cases and 62.2% of controls. Mean energy, protein, carbohydrate and fat intake was significantly lower for the case group. There was greater prevalence of inadequate zinc intake in the case group (35%) compared to control group (27%). Mean plasma zinc was significantly lower in the case group than in control group (77.13 ± 22.21 vs. 87.84 ± 17.44 µgZn/dL) (p=0.05). Urinary zinc did not differ significantly between cases and controls (p=0.155). In the case group, urinary plasma and zinc concentrations were below-reference values in 50.0% and 52.6% of patients, respectively. It was found that a 1µg/dL increase in plasma zinc lowered the odds of ALS by 3.6%. A large portion of patients with ALS exhibited changes in body zinc status, demonstrated by the low plasma zinc concentration and low food intake. The zinc deficiency found in half of the ALS patients may contribute to a worsened prognosis in patients with ALS and should be the target of nutritional interventions that aim to correct this deficiency.

MEMBROS DA BANCA:
Externo à Instituição - JOVANY LUIS ALVES MEDEIROS - UEPB
Presidente - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA
Externo ao Programa - 4659679 - SANCHA HELENA DE LIMA VALE