Banca de QUALIFICAÇÃO: MYCHELLE KYTCHIA RODRIGUES NUNES DUARTE

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : MYCHELLE KYTCHIA RODRIGUES NUNES DUARTE
DATA : 28/07/2016
HORA: 14:00
LOCAL: Sala de aula 07 do Departamento de Nutrição - DNUT/UFRN.
TÍTULO:

The relationship of the oleic acid level and ECHDC3 mRNA expression with the extent of coronary lesion.

PALAVRAS-CHAVES:

Oleic acid, gene expression, cardiovascular disease, atherosclerosis, index Friesinger. ECHDC3.

PÁGINAS: 66
GRANDE ÁREA: Ciências da Saúde
ÁREA: Nutrição
RESUMO:

The fatty acid profile is associated with the risk and progression of several diseases, probably via mechanisms including its influence on gene expression. We previously reported a correlation between ECHDC3 upregulation and the severity of acute coronary syndrome. Here, we assessed the relationship of serum fatty acid profile and ECHDC3 expression with the extent of coronary lesion.

Research Methods & Procedures

Fifty-nine individuals aged 30 to 74 years and undergoing elective cinecoronariography for the first time were enrolled in the present study. The extent of coronary lesion was assessed by the Friesinger index and patients were classified as without lesion (n = 18), low lesion (n = 17), intermediate lesion (n = 17) and major lesion (n = 7). Serum biochemistry, fatty acid concentration, and ECHDC3 mRNA expression in blood were evaluated.

Results

Elevated serum levels of oleic acid and total monounsaturated fatty acids were observed in patients with low and intermediate lesion, when compared to patients without lesion (p < 0.05). ECHDC3 mRNA expression was 1.2 fold higher in patients with low lesion than in patients without lesion (p = 0.023), and 1.8 fold lower in patients with major lesion patients than in patients with low lesion (p = 0.020).

Conclusion

Increased levels of monounsaturated fatty acids, especially oleic acid, and ECHDC3 upregulation in patients with coronary artery lesion suggests that these are independent factors associated with the initial progression of cardiovascular disease.

MEMBROS DA BANCA:
Interno - 2323511 - ADRIANA AUGUSTO DE REZENDE
Interno - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA
Presidente - 1804884 - VIVIAN NOGUEIRA SILBIGER