Banca de DEFESA: FABIANA MARIA COIMBRA DE CARVALHO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : FABIANA MARIA COIMBRA DE CARVALHO
DATA : 29/07/2016
HORA: 14:00
LOCAL: Auditório da Superintendência de Infraestrutura - SIN/UFRN.
TÍTULO:

A trypsin inhibitor from tamarind reduces food intake and improves inflammatory status in rats with metabolic syndrome regardless of weight loss.

PALAVRAS-CHAVES:

Obesity, Cafeteria diet, TNF-α. Glycemia.

PÁGINAS: 68
GRANDE ÁREA: Ciências da Saúde
ÁREA: Nutrição
RESUMO:

Trypsin inhibitors are studied in a variety of models for their anti-obesity and anti-inflammatory bioactive properties. Our group has previously demonstrated the satietogenic effect of tamarind seed trypsin inhibitors (TTI) in eutrophic mouse models and anti-inflammatory effects of other trypsin inhibitors. In this study, we evaluated TTI effect upon satiety, biochemical and inflammatory parameters in an experimental model of metabolic syndrome (MetS). Three groups of n=5 male Wistar rats with obesity-based MetS received for 10 days one of the following: 1) Cafeteria diet; 2) Cafeteria diet + TTI (25 mg/Kg); 3) Standard diet. TTI reduced food intake in animals with MetS. Nevertheless, weight gain was not different between studied groups. Dyslipidemia parameters were not different with the use of TTI, only the group receiving standard diet showed lower VLDL and TG (Kruskal-Wallis, p < 0.05). IL-6 production did not differ between groups. Interestingly, TNF-α was lower in animals receiving TTI. Our results corroborate the satietogenic effect of TTI in a MetS model. Furthermore, we show that TTI used with a cafeteria diet may decrease inflammation regardless of weight loss. This puts TTI as a candidate for studies to test its effectiveness as an adjuvant in MetS treatment.  

MEMBROS DA BANCA:
Interno - 2323511 - ADRIANA AUGUSTO DE REZENDE
Presidente - 2578619 - ANA HELONEIDA DE ARAUJO MORAIS
Externo à Instituição - DAVI FELIPE FARIAS - UFPB